Knowledge about cancer genetics is rapidly expanding and has implications for all aspects of cancer research and treatment, including molecular causation, diagnosis, prevention, screening, and treatment. Additionally, while cancer genetics has traditionally focused on mutational events that have their primary effect within the cancer cell, recently the focus has widened, with evidence of the importance of epigenetic events and of cellular interactions in cancer development. The role of common genetic variation in determining the range of individual susceptibility within the population is increasingly recognized, and is now being widely addressed using information from the Human Genome Project. These new research directions will highlight determinants of cancer that lie outside the cancer cell, suggest new targets for intervention, and inform the design of strategies for prevention in groups at increased risk.
This book series is the first to house a wide range of books whose focus is on cancer genetics and epigenetics. The first year of the series will be devoted to a study of genetic susceptibility of cancer, with the top names in this field editing volumes in their area of specialty.