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Structure and Dynamics of Confined Polymers

Proceedings of the NATO Advanced Research Workshop on Biological, Biophysical & Theoretical Aspects of Polymer Structure and Transport Bikal, Hungary 20–25 June 1999

  • Conference proceedings
  • © 2002

Overview

Editors:
  1. John J. Kasianowicz

    1. Biotechnology Division, National Institute of Standards and Technology, Gaithersburg, USA

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  2. Miklós S. Z. Kellermayer

    1. Department of Biophysics, Pécs University Medical School, Pécs, Hungary

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  3. David W. Deamer

    1. Biophysics Laboratory, Department of Chemistry and Biochemistry, University of California, Santa Cruz, USA

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Part of the book series: NATO Science Partnership Subseries: 3 (ASHT, volume 87)

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Table of contents (23 papers)

  1. Front Matter

    Pages i-xvii
    Download chapter PDF

  2. Profound Implications for Biophysics of the Polymer Threading a Membrane Transition

    • Edmund A. DiMarzio
    Pages 1-21

  3. Phage DNA Transport Across Membranes

    • Lucienne Letellier
    Pages 23-36

  4. Translocation of Macromolecules across Membranes and Through Aqueous Channels

    • Sanford M. Simon
    Pages 37-66

  5. Protein Translocation Across the Outer Membrane of Mitochondria

    • Stephan Nussberger, Walter Neupert
    Pages 67-84

  6. Protein Translocation Channels in Mitochondria

    • Kathleen W. Kinnally
    Pages 85-95

  7. Sizing Channels with Neutral Polymers

    • O. V. Krasilnikov
    Pages 97-115

  8. Dynamic Partitioning of Neutral Polymers into a Single Ion Channel

    • Sergey M. Bezrukov, John J. Kasianowicz
    Pages 117-130

  9. Branched Polymers inside Nanoscale Pores

    • C. Gay, P.-G. de Gennes, E. Raphaël, F. Brochard-Wyart
    Pages 131-139

  10. Physics of DNA Threading through a Nanometer Pore and Applications to Simultaneous Multianalyte Sensing

    • John J. Kasianowicz, Sarah E. Henrickson, Martin Misakian, Howard H. Weetall, Baldwin Robertson, Vincent Stanford
    Pages 141-163

  11. Mechanism of Ionic Current Blockades during Polymer Transport through Pores of Nanometer Dimensions

    • David W. Deamer, Hugh Olsen, Mark A. Akeson, John J. Kasianowicz
    Pages 165-175

  12. Using Nanopores to Discriminate between Single Molecules of DNA

    • Daniel Branton, Amit Meller
    Pages 177-185

  13. Use of a Nanoscale Pore to Read Short Segments within Single Polynucleotide Molecules

    • Mark Akeson, David W. Deamer, Wenonah Vercoutere, Rebecca Braslau, Hugh Olsen
    Pages 187-200

  14. Polymer Dynamics in Microporous Media

    • Björn Åkerman
    Pages 201-225

  15. Entropic Barrier Theory of Polymer Translocation

    • Murugappan Muthukumar
    Pages 227-239

  16. Polymer Translocation through a “Complicated” Pore

    • David K. Lubensky
    Pages 241-259

  17. The Polymer Barrier Crossing Problem

    • Wokyung Sung, Pyeong Jun Park
    Pages 261-280

  18. Brownian Ratchets and Their Application to Biological Transport Processes and Macromolecular Separation

    • Imre Derényi, R. Dean Astumian
    Pages 281-294

  19. Composition and Structural Dynamics of Vertebrate Striated Muscle Thick Filaments

    • Zoya A. Podlubnaya
    Pages 295-309

  20. Force-Driven Folding and Unfolding Transitions in Single Titin Molecules

    • Miklós S. Z. Kellermayer, Steven Smith, Carlos Bustamante, Henk L. Granzier
    Pages 311-326
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Keywords

About this book

Polymers are essential to biology because they can have enough stable degrees of freedom to store the molecular code of heredity and to express the sequences needed to manufacture new molecules. Through these they perform or control virtually every function in life. Although some biopolymers are created and spend their entire career in the relatively large free space inside cells or organelles, many biopolymers must migrate through a narrow passageway to get to their targeted destination. This suggests the questions: How does confining a polymer affect its behavior and function? What does that tell us about the interactions between the monomers that comprise the polymer and the molecules that confine it? Can we design and build devices that mimic the functions of these nanoscale systems? The NATO Advanced Research Workshop brought together for four days in Bikal, Hungary over forty experts in experimental and theoretical biophysics, molecular biology, biophysical chemistry, and biochemistry interested in these questions. Their papers collected in this book provide insight on biological processes involving confinement and form a basis for new biotechnological applications using polymers. In his paper Edmund DiMarzio asks: What is so special about polymers? Why are polymers so prevalent in living things? The chemist says the reason is that a protein made of N amino acids can have any of 20 different kinds at each position along the chain, resulting in 20 N different polymers, and that the complexity of life lies in this variety.

Editors and Affiliations

  • Biotechnology Division, National Institute of Standards and Technology, Gaithersburg, USA

    John J. Kasianowicz

  • Department of Biophysics, Pécs University Medical School, Pécs, Hungary

    Miklós S. Z. Kellermayer

  • Biophysics Laboratory, Department of Chemistry and Biochemistry, University of California, Santa Cruz, USA

    David W. Deamer

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