Biophysics and Physiology of Carbon Dioxide

1. Front Matter

   Pages I-XIV

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2. Chemical Reactions of CO2 in Water

   1. Front Matter

      Pages 1-1

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   2. Chemical Reactions of CO2 in Water

      • W. Knoche

      Pages 3-11

3. Facilitated Diffusion of CO2

   1. Front Matter

      Pages 13-13

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4. Facilitated Diffusion of CO2

   1. Facilitation of CO2 Through Layers with a Spatial Distribution of Carbonic Anhydrase

      • J. S. Schultz

      Pages 15-22

   2. Facilitated Diffusion of CO2 and Carbonic Anhydrase Activity

      • J. A. Quinn, T. L. Donaldson

      Pages 23-35

   3. Mechanisms of Facilitated CO2 and H+ Diffusion in Protein Solutions

      • G. Gros, H. Gros, D. Lavalette, B. Amand, F. Pochon

      Pages 36-48

   4. The Effect of Diffusion Potentials on Facilitated CO2 Diffusion

      • J. H. Meldon

      Pages 49-57

   5. Evidence for Facilitated Transport of CO2 in Muscle Tissue

      • P. Scheid, T. Kawashiro, J. Piiper

      Pages 58-63

5. Carbamate Reactions of Proteins

   1. Front Matter

      Pages 65-65

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   2. The Binding of CO2 to Human Deoxyhemoglobin: An X-Ray Study Using Low-Salt Crystals

      • A. Arnone, P. H. Rogers, P. D. Briley

      Pages 67-74

   3. The Determination of CO2 Bound to Hemoglobin as Carbamate

      • M. Perrella, L. Rossi-Bernardi

      Pages 75-83

   4. Phylogeny and Physiological Significance of Oxygen-Linked CO2 Binding in Hemoglobin

      • C. Bauer

      Pages 84-88

   5. The Carbamate Reaction with Proteins: Observation by 13C-NMR and Evaluation of Structural Consequences

      • F. R. N. Gurd, J. B. Matthew, R. J. Wittebort, J. S. Morrow, S. H. Friend

      Pages 89-101

   6. The Measurement of the CO2 Hb Binding Curve of Human Hemoglobin by 13C-NMR Spectrometry

      • O. Burkhard, W. K. R. Barnikol

      Pages 102-105

   7. Formation and Physiological Role of Carbamino Adducts of Angiotensin, Bradykinin, and S-Methylglucagon

      • R. S. Gurd, R. D. England, D. F. Hayes, R. J. Wittebort, T. M. Rothgeb

      Pages 106-113

   8. Interaction Between Hemoglobins, CO2 and Anions

      • R. Baumann

      Pages 114-121

   9. The Influence of CO2 on the First Binding Constant of Oxygen to Human Hemoglobin Ao

      • C. Poyart, E. Bursaux, P. Matzke

      Pages 122-129

6. Carbonic Anhydrase — Structure and Function

   1. Front Matter

      Pages 131-131

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   2. Current Concepts of the Mechanism of Action of Carbonic Anhydrase

      • J. E. Coleman

      Pages 133-150

This volume contains the papers presented at the symposium on Biophysics and Physiology of Carbon Dioxide held at Regensburg, April 17-20, 1979. The manuscripts represent the full or even an extended account of the oral presentations. We have decided not to include any part of the discussions which took place after the lectures because this would have led to an undue enlargement of the already substantial volume. The symposium brought together some 60 scientists of various disciplines including biophysicists, chemists, biochemists, physiologists, pharmacologists, as well as clinicians whose research activities are cen­ tered around the various aspects of the reactions and the regulatory role of CO within the body. 2 In view of the fact that numerous textbooks and Proceedings of Symposia deal expertly with the role of CO in acid-base balance, it 2 was decided not to include this aspect in the present symposium. This holds also for the biochemistry of carboxylation and decarboxylation reactions. Particular emphasis was placed on the following subjects: (1) Chemical reactions of CO in water and facilitated diffusion of CO2 , 2 (2) CO adducts to proteins, in particular hemoglobin, and peptide 2 hormones, (3) structure and function of carbonic anhydrase, (4) CO 2 exchange and carbonic anhydrase activity in respiratory and nonrespi­ ratory systems. Each section contains at least one introductory paper that presents the current knowledge in a more general framework.

• Carbon
• Dioxide
• Karbonatdehydratase
• Kohlendioxid
• Peptide
• biophysics
• physiology
• proteins

• Institut für Physiologie, Universität Regensburg, Regensburg, Germany

  Christian Bauer

• Institut für Physiologie, Universitätsklinikum Essen, Essen, Germany

  Gerolf Gros

• Physiologisches Institut, Medizinische Hochschule Hannover, Hannover 61, Germany

  Heinz Bartels

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