Logo - springer
Slogan - springer

Physics - Biophysics & Biological Physics | Modelling the Short QT Syndrome Gene Mutations - And Their Role in Cardiac Arrhythmogenesis

Modelling the Short QT Syndrome Gene Mutations

And Their Role in Cardiac Arrhythmogenesis

Series: Springer Theses

Adeniran, Ismail

2014, XVII, 217 p. 102 illus., 38 illus. in color.

Available Formats:

Springer eBooks may be purchased by end-customers only and are sold without copy protection (DRM free). Instead, all eBooks include personalized watermarks. This means you can read the Springer eBooks across numerous devices such as Laptops, eReaders, and tablets.

You can pay for Springer eBooks with Visa, Mastercard, American Express or Paypal.

After the purchase you can directly download the eBook file or read it online in our Springer eBook Reader. Furthermore your eBook will be stored in your MySpringer account. So you can always re-download your eBooks.


(net) price for USA

ISBN 978-3-319-07200-5

digitally watermarked, no DRM

Included Format: PDF and EPUB

download immediately after purchase

learn more about Springer eBooks

add to marked items


Hardcover version

You can pay for Springer Books with Visa, Mastercard, American Express or Paypal.

Standard shipping is free of charge for individual customers.


(net) price for USA

ISBN 978-3-319-07199-2

free shipping for individuals worldwide

usually dispatched within 3 to 5 business days

add to marked items

  • Nominated as an outstanding Ph. D. thesis by the University of Manchester, UK
  • Presents multiphysics modelling of the human heart from ion channel to cell to whole organ
  • Provides a functional analysis of the impact of gene mutations on cardiac arrhythmogenesis
  • Comprehensive detail of predictive physiology
The Short QT Syndrome (SQTS) is characterized by abbreviated QT intervals on the electrocardiogram, increased risk of cardiac arrhythmias and sudden death. Although several gene mutations have been identified in SQT patients, the role of these mutations in promoting arrhythmogenesis is still not completely understood. Consequently, this thesis employs multidisciplinary approaches to develop a 3D virtual heart, which is then used to elucidate how the short QT syndrome facilitates and maintains ventricular arrhythmias and to determine its effects on ventricular mechanical contraction. The findings in this thesis provide a comprehensive and mechanistic explanation for a number of gene mutations associated with potassium channels in terms of susceptibility to arrhythmia. The multiphysics models developed provide a powerful platform for identifying the root causes of various arrhythmias and investigating therapeutic interventions for these diseases. 
The thesis was examined by Prof. Chris Huang of the University of Cambridge, the most authoritative figure in cardiac electrophysiology, who has described the work as “outstanding.”

Content Level » Research

Keywords » 3D Virtual Heart - Arrhythmia Simulation with Virtual Heart - Gene Mutations Inducing Heart Arrhythmia - Human Ventricles - Markov Models - Multiphysics Models of Heart Arrhythmia - Potassium Channels and Heart Arrhythmia - Short QT Syndrome - Stretch-activated Channel - Ventricular Arryhthmias - Ventricular Fibrillation

Related subjects » Biophysics & Biological Physics - Cardiology & Angiology - Cell Biology - Complexity - Theoretical, Mathematical & Computational Physics

Table of contents / Sample pages 

Popular Content within this publication 



Read this Book on Springerlink

Services for this book

New Book Alert

Get alerted on new Springer publications in the subject area of Biological Networks, Systems Biology.