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Physics - Biophysics & Biological Physics | Mechanisms of Atrial Arrhythmias - Insights from the Development of a Biophysically Detailed Model

Mechanisms of Atrial Arrhythmias

Insights from the Development of a Biophysically Detailed Model of the Human Atria

Series: Springer Theses

Colman, Michael A.

2014, XXII, 256 p. 137 illus., 42 illus. in color.

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  • Nominated as an outstanding Ph.D. thesis by the University of Manchester, UK
  • Elucidates the mechanisms underlying atrial fibrillation
  • May assist in the prevention and treatment of atrial fibrillation
  • Provides detailed, multi-scale model of the heterogeneous human atria and torso
  • Provides models of anatomically accurate and electrophysiologically detailed pacemaker structures
This thesis describes the development of biophysically detailed computer models of the human atria and torso to study the underlying mechanisms of cardiac diseases, some of the most common causes of morbidity and mortality. This is a cross-disciplinary project, involving fundamentals of cardiac electrophysiology, physics of excitable media, applied mathematics and high performance scientific computing and visualisation.  The author uses computer models to provide insights into the underlying mechanisms of the genesis of atrial fibrillation and develops novel techniques for the monitoring of atrial tachycardia. 

Content Level » Research

Keywords » 3D Anatomical Modelling of the Atria - Atrial Fbrillation - Atrial Tchycardia - Autonomic Crdiac Rgulation - Cardiac Mdelling - Electrical Rmodelling - Electrophysiological Mdelling - Pacemaking Mehanisms

Related subjects » Biophysics & Biological Physics - Cardiology & Angiology - Systems Biology and Bioinformatics - Theoretical, Mathematical & Computational Physics

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