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Nominated as an outstanding Ph.D. thesis by the University of Aberdeen, UK
Includes the first computational model of the entire cell cycle and its interaction with the osmotic stress response network
Presents a comprehensive model that yields a set of novel predictions to guide further experiments
Also applies the model's predictions to higher eukaryotes
The cell cycle is a sequence of biochemical events that are controlled by complex but robust molecular machinery. This enables cells to achieve accurate self-reproduction under a broad range of conditions. Environmental changes are transmitted by molecular signaling networks, which coordinate their actions with the cell cycle.
This work presents the first description of two complementary computational models describing the influence of osmotic stress on the entire cell cycle of S. cerevisiae. Our models condense a vast amount of experimental evidence on the interaction of the cell cycle network components with the osmotic stress pathway. Importantly, it is only by considering the entire cell cycle that we are able to make a series of novel predictions which emerge from the coupling between the molecular components of different cell cycle phases.
The model-based predictions are supported by experiments in S. cerevisiae and, moreover, have recently been observed in other eukaryotes. Furthermore our models reveal the mechanisms that emerge as a result of the interaction between the cell cycle and stress response networks.
Content Level »Research
Keywords »Accelerated Exit from Mitosis - Boolean Model of Cell Cycle Stress Response - Cell Cycle Stress Responses - Cell Cycle of S. Cerevisiae - Computational Model of Cell Cycle Stress - DNA Re-replication Under Stress - Mathematical Models of Cell Cycle Stress - Osmotic Stress and Cell Cycle Regulation