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Physics - Biophysics & Biological Physics | Intracellular Signaling Mediators in the Circulatory and Ventilatory Systems

Intracellular Signaling Mediators in the Circulatory and Ventilatory Systems

Thiriet, Marc

2013, XV, 1064 p. 31 illus.

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  • Reviews signaling pathways in the regulation of circulatory and respiratory function
  • Describes ion and molecular carriers and receptors
  • Integrates biology, chemistry, and physics for a multidisciplinary understanding of physiological flows

The volumes in this authoritative series present a multidisciplinary approach to modeling and simulation of flows in the cardiovascular and ventilatory systems, especially multiscale modeling and coupled simulations. The cardiovascular and respiratory systems are tightly coupled, as their primary function is to supply oxygen to and remove carbon dioxide from the body's cells. Because physiological conduits have deformable and reactive walls, macroscopic flow behavior and prediction must be coupled to phenomenological models of nano- and microscopic events in a corrector scheme of regulated mechanisms when the vessel lumen caliber varies markedly. Therefore, investigation of flows of blood and air in physiological conduits requires an understanding of the biology, chemistry, and physics of these systems together with the mathematical tools to describe their functioning.

Volume 4 is devoted to major sets of intracellular mediators that transmit signals upon stimulation of cell-surface receptors.  Activation of signaling effectors triggers the release of substances stored in cellular organelles and/or gene transcription and protein synthesis. Complex stages of cell signaling can be studied using proper mathematical models, once the role of each component is carefully handled.  Volume 4 also reviews various categories of cytosolic and/or nuclear mediators and illustrates some major signal transduction pathways, such as NFkappaB axis, oxygen sensing, and mechanotransduction.

Reviews signaling pathways in the regulation of circulatory and respiratory function

Describes ion and molecular carriers and receptors

Integrates biology, chemistry, and physics for a multidisciplinary understanding of physiological flows

Content Level » Research

Keywords » blood flow behavior - blood flow prediction - cardiovascular systems modeling - cell signalling pathways - ion and molecule carriers described - modeling respiratory function - modeling simulation of flows - physiological flows - receptors ligands - signaling mediators explained - ventilatory systems modeling

Related subjects » Biomedical Engineering - Biophysics & Biological Physics - Cardiology & Angiology - Mechanics

Table of contents 

1. Introduction
2. Signaling Lipids
3. Preamble to Cytoplasmic Protein Kinases
4. Cytoplasmic Protein Tyrosine Kinases
5. Cytoplasmic Protein Serine/Threonine Kinases
6. Dual-Specificity Protein Kinases
7. Mitogen-Activated Protein Kinase Module
8. Dual-Specificity Protein Kinases
9. Guanosine Triphosphatases and Their Regulators
10. Other Major Types of Signaling Mediators
11. Signaling Pathways
12. Conclusion
References
List of Currently Used Prefixes and Suffixes
List of Aliases
Complementary Lists of Notations
Index

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