Springer eBooks may be purchased by end-customers only and are sold without copy protection (DRM free). Instead, all eBooks include personalized watermarks. This means you can read the Springer eBooks across numerous devices such as Laptops, eReaders, and tablets.
You can pay for Springer eBooks with Visa, Mastercard, American Express or Paypal.
After the purchase you can directly download the eBook file or read it online in our Springer eBook Reader. Furthermore your eBook will be stored in your MySpringer account. So you can always re-download your eBooks.
Critically examines existing models of structure-function relations, guided by experimental data and physical principles
Unifies topics from electrophysiology, condensed-state physics, polymer chemistry and genetic engineering as they bear on the problem of molecular excitability
Develops a new physics-based approach, gateless gating, to the problem of molecular excitability
Deals with optical, thermal and mechanical as well as electrical measurements - in the frequency domain as well as the time domain
Topics are introduced at an elementary level and terms are clearly defined
Voltage-sensitive ion channels are macromolecules embedded in the membranes of nerve and muscle fibers of animals. Because of their physiological functions, biochemical structures and electrical switching properties, they are at an intersection of biology, chemistry and physics. Despite decades of intensive research under the traditional approach of gated structural pores, the relation between the structure of these molecules and their function remains enigmatic.
This book critically examines physically oriented approaches not covered in other ion-channel books. It looks at optical and thermal as well as electrical data, and at studies in the frequency domain as well as in the time domain. Rather than presenting the reader with only an option of mechanistic models at an inappropriate pseudo-macroscopic scale, it emphasizes concepts established in organic chemistry and condensed state physics. The book’s approach to the understanding of these unique structures breaks with the unproven view of ion channels as structurally gated pores. Rather, it proposes gateless gating, in which the onset and cessation of avalanches of ions crossing the membrane is explained as a c
Content Level »Research
Keywords »animals - biology - biophysics - chemistry - condensed matter - electrophysiology - information - organic chemistry - physiology - protein - system
PREFACE; 1. EXPLORING EXCITABILITY; 2. INFORMATION IN THE LIVING BODY, 3. ANIMAL ELECTRICITY; 4. ELECTROPHYSIOLOGY OF THE AXON; 5. ASPECTS OF CONDENSED MATTER; 6. IONS IN THE ELECTRIC FIELD; 7. IONS DRIFT AND DIFFUSE; 8. MULTI-ION AND TRANSIENT; 9. MODELS OF MEMBRANE EXCITABILITY; 10. ADMITTANCE TO THE SEMICIRCLE; 11. WHAT’S THAT NOISE? 12. ION CHANNELS, PROTEINS AND TRANSITIONS; 13. DIVERSITY AND STRUCTURES OF ION CHANNELS; 14. MICROSCOPIC MODELS OF CHANNEL FUNCTION; 15. ORDER FROM DISORDER; 16. POLAR PHASES; 17. DELICATE PHASES AND THEIR TRANSITIONS; 18. PROPAGATION AND PERCOLATION IN A CHANNEL; 19. SCREWS AND HELICES; 20. VOLTAGE-INDUCED GATING OF ION CHANNELS; 21. BRANCHING OUT; INDEX.