Overview
- Critically examines existing models of structure--function relations, guided by experimental data and physical principles
- Unifies topics from electrophysiology, condensed-state physics, polymer chemistry and genetic engineering as they bear on the problem of molecular excitability
- Deals with optical, thermal and mechanical as well as electrical measurements -- in the frequency domain as well as the time domain
- Topics are introduced at an elementary level, and terms are clearly defined because the book is intended to attract readers from a wide range of disciplines
- Develops a new physics-based approach, gateless gating, to the problem of molecular excitability
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Table of contents (21 chapters)
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Front Matter
Keywords
About this book
Reviews
From the reviews:
"...this well-written and thoroughly researched book is Dr. Leuchtag’s crowning achievement as it presents ion channel structure and function painted on a broad canvass of biological, physical and mathematical backdrop that is needed to properly understand these small yet hugely important biological switches."
Prof. Jack Tuszynski: Allard Research Chair Division of Experimental Oncology, Room 3336, Cross Cancer Institute, 11560 University Avenue, Edmonton, AB T6G 1Z2 Canada
"… This book is an impressive sum of more than 500 pages dealing with conventional as well as unconventional views on excitability and channels with some historic remainders on animal electricity and general considerations on ‘information in the living body’ including primitive forms such as bacteria swimming… Professor Leuchtag’s book is well written, easy to read, despite necessary theoretical disgressions, resulting in a real interdisciplinary account (even sometimes thought-provoking) of what is presently known about voltage-sensitive ion channels and molecular excitability."
Hervé Duclohier is in the Physiopathology and Pharmacology of Ion Channels Group, UMR 6187-Université de Poitiers, 40 Avenue du Recteur Pineau, 86022 POITIERS (France). E-mail : Herve.Duclohier@univ-poitiers.fr
"… Voltage-sensitive ion channels are macromolecules embedded in the membranes of nerve and muscle fibers of animals. Because of their physiological functions, biochemical structures and electrical switching properties, they are at an intersection of biology, chemistry and physics… The book is very well referenced…and is a challenge for physicists and biologists alike…Experts in both fields, as well as young graduates will certainly benefit from the vast amount of information collected; moreover, they may be motivated for an exciting journey to living matter from aphysical perspective."
Alexander G. Petrov, PhD, DSc, FBAS, Director, Institute of Solid State Physics, Bulgarian Academy of Sciences, Sofia
Bibliographic Information
Book Title: Voltage-Sensitive Ion Channels
Book Subtitle: Biophysics of Molecular Excitability
Editors: H. Richard Leuchtag
DOI: https://doi.org/10.1007/978-1-4020-5525-6
Publisher: Springer Dordrecht
eBook Packages: Physics and Astronomy, Physics and Astronomy (R0)
Copyright Information: Springer Science+Business Media B.V. 2008
Hardcover ISBN: 978-1-4020-5524-9Published: 25 January 2008
Softcover ISBN: 978-90-481-7384-6Published: 19 October 2010
eBook ISBN: 978-1-4020-5525-6Published: 21 December 2008
Edition Number: 1
Number of Pages: XXIV, 532
Topics: Biological and Medical Physics, Biophysics, Animal Physiology, Soft and Granular Matter, Complex Fluids and Microfluidics, Animal Biochemistry, Neurobiology