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Multidisciplinary approach starting from the description of accumulated knowledge on the biology of the cardiovascular system to the numerical simulation of flows in the vasculature, incorporating rheology and mechanical data
Applications of modeling and simulations on health problems as well as therapeutic strategies
State-of-the-art in applied mathematics to physiological flows
Biological and mechanical glossaries for easy reading
Biology and Mechanics of Blood Flows presents the basic knowledge and state-of-the-art techniques necessary to carry out investigations of the cardiovascular system using modeling and simulation. Part I of this two-volume sequence, Biology, addresses the nanoscopic and microscopic scales. The nanoscale corresponds to the scale of biochemical reaction cascades involved in cell adaptation to mechanical stresses among other stimuli. The microscale is the scale of stress-induced tissue remodeling associated with acute or chronic loadings. The cardiovascular system, like any physiological system, has a complicated three-dimensional structure and composition. Its time dependent behavior is regulated, and this complex system has many components. In this authoritative work, the author provides a survey of relevant cell components and processes, with detailed coverage of the electrical and mechanical behaviors of vascular cells, tissues, and organs. Because the behaviors of vascular cells and tissues are tightly coupled to the mechanics of flowing blood, the major features of blood flows and the Navier-Stokes equations of mass and momentum conservation are introduced at the conclusion of this volume. This book will appeal to any biologist, chemist, physicist, or applied mathematician with an interest in the functioning of the cardiovascular system.
The Cell.- Plasma Membrane and Cell Environment.- Ion Carriers and Receptors.- Signaling Pathways.- Transport and Cell Motion.- Blood.- Heart Wall.- Vessel Wall.- Endothelium.- Tissue Growth, Repair, and Remodeling.