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Inflammation

  • Book
  • © 1978

Overview

Editors:
  1. John R. Vane

    1. The Wellcome Research Laboratories, Beckenham, Kent, UK

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    You can also search for this editor in PubMed   Google Scholar

  2. Sergio H. Ferreira

    1. Faculdade de Medicina de Ribeirão Preto, Universidade de São Paulo, São Paulo, Brazil

    View editor publications

    You can also search for this editor in PubMed   Google Scholar

Part of the book series: Handbook of Experimental Pharmacology (HEP, volume 50 / 1)

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Table of contents (19 chapters)

  1. Front Matter

    Pages I-XXVII
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  2. Historical Survey of Definitions and Concepts of Inflammation

    1. Historical Survey of Definitions and Concepts of Inflammation

      • S. E. Smith
      Pages 1-4

  3. The Inflammatory Reaction

    1. Front Matter

      Pages 5-5
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    2. A Brief History of Inflammation

      • M. Rochae E Silva
      Pages 6-25

    3. The Sequence of Early Events

      • J. V. Hurley
      Pages 26-67

    4. Mononuclear Phagocytes in Inflammation

      • R. van Furth
      Pages 68-108

    5. The Adhesion, Locomotion, and Chemotaxis of Leucocytes

      • P. C. Wilkinson
      Pages 109-137

    6. Platelet Aggregation Mechanisms and Their Implications in Haemostasis and Inflammatory Disease

      • A. L. Willis
      Pages 138-205

    7. Regeneration and Repair

      • L. E. Glynn
      Pages 206-230

    8. Immunological and Para-Immunological Aspects of Inflammation

      • J. L. Turk, D. A. Willoughby
      Pages 231-266

    9. The Release of Hydrolytic Enzymes From Phagocytic and Other Cells Participating in Acute and Chronic Inflammation

      • P. Davies, A. C. Allison
      Pages 267-294

    10. Lysosomal Enzymes

      • R. B. Zurier, K. Krakauer
      Pages 295-313

    11. Lymphokines

      • J. Morley
      Pages 314-342

  4. Inflammatory Mediators Released From Cells

    1. Front Matter

      Pages 343-343
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    2. Histamine, 5-Hydroxytryptamine, SRS-A: Discussion of Type I Hypersensitivity (Anaphylaxis)

      • M. Plaut, L. M. Lichtenstein
      Pages 345-373

    3. Prostaglandins and Related Compounds

      • R. J. Flower
      Pages 374-422

  5. Inflammatory Mediators Generated by Activation of Plasma Systems

    1. Front Matter

      Pages 423-423
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    2. Complement

      • A. Nicholson, D. T. Fearon, K. F. Austen
      Pages 425-463

    3. Bradykinin-System

      • J. Garcia Leme
      Pages 464-522

    4. Endogenous Modulators of the Inflammatory Response

      • I. L. Bont
      Pages 523-567
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Keywords

About this book

Throughout the centuries, inflammation has been considered as a disease in itself. This misconception arose from the inability to distinguish between inflammatory changes and the insults which induce them. The understanding of the distinction between the genesis of inflammation and the tissue reactions that follow is attributed to JOHN HUNTER, who, at the end of the 18th century, substantially contributed to the analysis of inflammation in objective terms. Today, however, we are still trying to find explanations for Celsus' Signs in terms of structural and functional changes occurring in the inflamed tissue. There are drugs which modulate these signs but, without a detailed knowledge of the basic physiopathological events, it is impossible to understand their mechanism of action. Notwithstanding, the effects of anti­ inflammatory drugs provided new knowledge of the relevance of the signs and symptoms to the sequence of biochemical and morphological changes occurring in inflammation. When we accepted the invitation to edit a Handbook on Inflammation and Anti­ Inflammatory Drugs, we were aware of the magnitude of the task. We knew the impossibility of covering the whole field in detail, especially taking into account the rapid accumulation of experimental knowledge which would, in all likelihood, overtake the process of publication.

Editors and Affiliations

  • The Wellcome Research Laboratories, Beckenham, Kent, UK

    John R. Vane

  • Faculdade de Medicina de Ribeirão Preto, Universidade de São Paulo, São Paulo, Brazil

    Sergio H. Ferreira

Bibliographic Information

  • Book Title: Inflammation

  • Editors: John R. Vane, Sergio H. Ferreira

  • Series Title: Handbook of Experimental Pharmacology

  • DOI: https://doi.org/10.1007/978-3-642-66888-3

  • Publisher: Springer Berlin, Heidelberg

  • eBook Packages: Springer Book Archive

  • Copyright Information: Springer-Verlag Berlin Heidelberg 1978

  • Softcover ISBN: 978-3-642-66890-6Published: 12 November 2011

  • eBook ISBN: 978-3-642-66888-3Published: 27 November 2013

  • Series ISSN: 0171-2004

  • Series E-ISSN: 1865-0325

  • Edition Number: 1

  • Number of Pages: XXVIII, 786

  • Topics: Pharmacy, Immunology

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