Inflammation

1. Front Matter

   Pages I-XXVII

   PDF

2. Historical Survey of Definitions and Concepts of Inflammation

   1. Historical Survey of Definitions and Concepts of Inflammation

      • S. E. Smith

      Pages 1-4

3. The Inflammatory Reaction

   1. Front Matter

      Pages 5-5

      PDF

   2. A Brief History of Inflammation

      • M. Rochae E Silva

      Pages 6-25

   3. The Sequence of Early Events

      • J. V. Hurley

      Pages 26-67

   4. Mononuclear Phagocytes in Inflammation

      • R. van Furth

      Pages 68-108

   5. The Adhesion, Locomotion, and Chemotaxis of Leucocytes

      • P. C. Wilkinson

      Pages 109-137

   6. Platelet Aggregation Mechanisms and Their Implications in Haemostasis and Inflammatory Disease

      • A. L. Willis

      Pages 138-205

   7. Regeneration and Repair

      • L. E. Glynn

      Pages 206-230

   8. Immunological and Para-Immunological Aspects of Inflammation

      • J. L. Turk, D. A. Willoughby

      Pages 231-266

   9. The Release of Hydrolytic Enzymes From Phagocytic and Other Cells Participating in Acute and Chronic Inflammation

      • P. Davies, A. C. Allison

      Pages 267-294

   10. Lysosomal Enzymes

       • R. B. Zurier, K. Krakauer

       Pages 295-313

   11. Lymphokines

       • J. Morley

       Pages 314-342

4. Inflammatory Mediators Released From Cells

   1. Front Matter

      Pages 343-343

      PDF

   2. Histamine, 5-Hydroxytryptamine, SRS-A: Discussion of Type I Hypersensitivity (Anaphylaxis)

      • M. Plaut, L. M. Lichtenstein

      Pages 345-373

   3. Prostaglandins and Related Compounds

      • R. J. Flower

      Pages 374-422

5. Inflammatory Mediators Generated by Activation of Plasma Systems

   1. Front Matter

      Pages 423-423

      PDF

   2. Complement

      • A. Nicholson, D. T. Fearon, K. F. Austen

      Pages 425-463

   3. Bradykinin-System

      • J. Garcia Leme

      Pages 464-522

   4. Endogenous Modulators of the Inflammatory Response

      • I. L. Bont

      Pages 523-567

Throughout the centuries, inflammation has been considered as a disease in itself. This misconception arose from the inability to distinguish between inflammatory changes and the insults which induce them. The understanding of the distinction between the genesis of inflammation and the tissue reactions that follow is attributed to JOHN HUNTER, who, at the end of the 18th century, substantially contributed to the analysis of inflammation in objective terms. Today, however, we are still trying to find explanations for Celsus' Signs in terms of structural and functional changes occurring in the inflamed tissue. There are drugs which modulate these signs but, without a detailed knowledge of the basic physiopathological events, it is impossible to understand their mechanism of action. Notwithstanding, the effects of anti­ inflammatory drugs provided new knowledge of the relevance of the signs and symptoms to the sequence of biochemical and morphological changes occurring in inflammation. When we accepted the invitation to edit a Handbook on Inflammation and Anti­ Inflammatory Drugs, we were aware of the magnitude of the task. We knew the impossibility of covering the whole field in detail, especially taking into account the rapid accumulation of experimental knowledge which would, in all likelihood, overtake the process of publication.

• Chemokine
• Histamin
• Hypothalamus
• Insulin
• Nicotin
• Prostaglandin
• antibody
• antigen
• asthma
• biochemistry
• bronchial asthma
• chemistry
• inflammation
• neurotransmitter
• pharmacology

• The Wellcome Research Laboratories, Beckenham, Kent, UK

  John R. Vane

• Faculdade de Medicina de Ribeirão Preto, Universidade de São Paulo, São Paulo, Brazil

  Sergio H. Ferreira

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