Systems and Synthetic Biology

1. Front Matter

   Pages i-xi

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2. Systems Biology

   1. Front Matter

      Pages 1-1

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   2. Introduction to Systems Biology

      • Bin Hu, Pawan K. Dhar

      Pages 3-23

   3. Why Systems Biology Can Promote a New Way of Thinking

      • Alessandro Giuliani

      Pages 25-41

   4. Modelling Methodologies for Systems Biology

      • Vikram Singh

      Pages 43-62

   5. In silico Identification of Eukaryotic Promoters

      • Venkata Rajesh Yella, Manju Bansal

      Pages 63-75

   6. Hill Equation in Modeling Transcriptional Regulation

      • Silpa Bhaskaran, Umesh P., Achuthsankar S. Nair

      Pages 77-92

   7. Molecular Modeling

      • Preethi Badrinarayan, Chinmayee Choudhury, G. Narahari Sastry

      Pages 93-128

   8. Complex Networks and Systems Biology

      • Ushasi Roy, Rajdeep Kaur Grewal, Soumen Roy

      Pages 129-150

   9. Systems Approaches to Study Infectious Diseases

      • Priyanka Baloni, Soma Ghosh, Nagasuma Chandra

      Pages 151-172

   10. Systems Pharmacology and Pharmacogenomics for Drug Discovery and Development

       • Puneet Talwar, Yumnum Silla, Sandeep Grover, Meenal Gupta, Gurpreet Kaur Grewal, Ritushree Kukreti

       Pages 173-193

   11. Switching Mechanism in the p53 Regulatory Network

       • Mohammad Jahoor Alam, Vikram Singh, R. K. Brojen Singh

       Pages 195-216

   12. Systems Biology of MicroRNA

       • Remya Krishnan, Pawan K. Dhar

       Pages 217-225

3. Synthetic Biology

   1. Front Matter

      Pages 227-227

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   2. A Brief Introduction to Synthetic Biology

      • Mrugainduta Patil, Pawan K. Dhar

      Pages 229-240

   3. DNA Structure and Promoter Engineering

      • Venkata Rajesh Yella, Aditya Kumar, Manju Bansal

      Pages 241-254

   4. Synchronous Sequential Computations with Biomolecular Reactions

      • Vishwesh V. Kulkarni, Hua Jiang, Evgeny Kharisov, Naira Hovakimyan, Mark Riedel, Keshab Parhi

      Pages 255-279

   5. Designing Zinc Finger Proteins for Applications in Synthetic Biology

      • Shayoni Dutta, Durai Sundar

      Pages 281-297

   6. Synthetic Biology for the Development of Biodrugs and Designer Crops and the Emerging Governance Issues

      • Archana Chugh, Pooja Bhatia, Aastha Jain

      Pages 299-325

   7. Advancement of Emerging Tools in Synthetic Biology for the Designing and Characterization of Genetic Circuits

      • Vijai Singh, Indra Mani, Dharmendra Kumar Chaudhary

      Pages 327-339

This textbook has been conceptualized to provide a detailed description of the various aspects of Systems and Synthetic Biology, keeping the requirements of M.Sc. and Ph.D. students in mind. Also, it is hoped that this book will mentor young scientists who are willing to contribute to this area but do not know from where to begin. The book has been divided into two sections. The first section will deal with systems biology – in terms of the foundational understanding, highlighting issues in biological complexity, methods of analysis and various aspects of modelling. The second section deals with the engineering concepts, design strategies of the biological systems ranging from simple DNA/RNA fragments, switches and oscillators, molecular pathways to a complete synthetic cell will be described. Finally, the book will offer expert opinions in legal, safety, security and social issues to present a well-balanced information both for students and scientists.

• Biological Networks
• Biomedical Engineering
• Genetic Engineering
• Synthetic Biology
• Systems Biology
• biochemical engineering

• Centre for Computational Biology and Bioinformatics, Central University of Himachal Pradesh, Dharamshala, India

  Vikram Singh

• Department of Life Sciences, School of Natural Sciences, Shiv Nadar University, Gautam Budh Nagar, India

  Pawan K. Dhar

Policies and ethics