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New & Forthcoming Titles | ß-barrel Channel Proteins as Tools in Nanotechnology - Biology, Basic Science and Advanced Applications

ß-barrel Channel Proteins as Tools in Nanotechnology

Biology, Basic Science and Advanced Applications

Fioroni, Marco, Dworeck, Tamara, Rodriguez-Ropero, Francisco

2014, XII, 168 p. 45 illus., 29 illus. in color.

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  • Gives a comprehensible report on how to use beta-barrel membrane proteins as nano-material components (including all involved steps)
  • Is useful for both experimentalists and theoreticians that want to expand their knowledge toward the rapidly expanding field of membrane protein based bio-nanotechnology
  • Includes a chapter with "wet-lab" information on the beta-barrel membrane protein production (including trouble shootings and suggestions)

b-barrel outer membrane channel proteins (OMP) have great potential as robust and flexible models or components in nanotechnology. Over the last decade biotechnological techniques allowed to expand the natural characteristics of OMPs by modifying their geometry and properties without affecting the overall protein structure and stability. The present book is oriented towards a broad group of readers including graduate students and advanced researchers. The b-barrel structure serviceability for the nano-material design will be its chief topic giving a general introduction to the field of OMP based nano-component development as well as the state of the art of the involved research. On the example of the E. coli FhuA the transformation of an OMP into a tailored nano-channel to be adapted to a non-biological synthetic (i.e. polymer) environment, rendering it competitive with artificial non-biological nano-pores will be outlined specifically the design of a set of protein nano-channels with tailored geometry (diameter, length), conductance and functionality will be reported as a case study.

In order to make this book a valuable source of information for both biotechnologists and other scientists interested in bio-nanotechnology an overview of the different steps involved in the nano-channel protein design and production will be reported. The scientific strategy from concept design, theoretical considerations, genetic engineering and large scale production, to system assembly and biophysical characterization with an overview on technological applications including membrane/polymersome technology, will be described.

Content Level » Research

Keywords » beta-barrel membrane proteins - circular dichroism spectroscopy - multiscale modelling - nano-channels - polymersomes

Related subjects » Bioinformatics - Biotechnology - Human Genetics

Table of contents 

Preface.- Introduction.- Biology.- Biophysical Characterization.- Theoretical Considerations and Computational Tools.- Biotechnology.- Technological Applications.- Final Considerations. Index.

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