Theory and Diagnosis of Inhibition and Activation Mechanisms
2015, Approx. 400 p.
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Covers all known mechanisms of enzyme inhibition and activation
Only modern and robust methods are discussed
Includes step-by-step guided practical examples to accompany theoretical explanations
Shows diagnostic keys to enzyme-modifier interaction mechanisms that have never been published before
The monograph will not cover the fundamentals of enzyme kinetics because this topic is already treated in excellent books. However, basic theories will be shortly introduced in the first chapter as a prerequisite for the applications following in the successive chapters. The second/third chapter(s) will cover the statistical evaluation of kinetic data and numerical integration methods. The treatment of enzyme-modifier interactions will unify inhibition and activation (classical and tight-binding), with emphasis on allosteric regulation, for which there is a growing interest in pharmacological applications. Physiologically and pharmacologically relevant ‘slow’ interactions between enzymes and modifiers will be treated in a unified theory for reversible and irreversible processes. Diagnostic dichotomous keys to the mechanisms will be placed at the end of the monograph. Essential mathematical derivations not presented elsewhere in the literature will be written as appendix.