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"The book is mainly a research reference book but may be of interest for graduate students specializing in the fields of cell physiology and signal transduction. The book is an excellent, up-to-date survey for those who wish to learn about the state of calcium dynamic modelling and how such models are applied to physiological questions … . Much of the underlying physiology is clearly presented to help the reader to follow the modelling." (Johnny Tom Ottesen, Mathematical Reviews, Issue 2006 h)