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New & Forthcoming Titles | Protein Folding - An Introduction

Protein Folding

An Introduction

Gomes, Claudio M., Faisca, Patricia F.N.

2015, 100 p. 30 illus., 10 illus. in color.

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ISBN 978-3-319-00882-0

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  • About this book

  • Provides a snapshot of the field of protein folding
  • Presents a unique resource for newcomers to the field
  • Indicates further reading from the current literature
This snapshot volume is designed to provide a smooth entry into the field of protein folding. Presented in a concise manner, each section introduces key concepts while providing a brief overview of the relevant literature. Outlook subsections will pinpoint specific aspects related to emerging methodologies, concepts and trends.

Content Level » Research

Keywords » Folding Kinetics - Folding Thermodynamics - Molecular Simulations - Protein Folding in the Cell - Protein Misfolding and Disease - Single Molecule Experiments

Related subjects » Organic Chemistry

Table of contents 

Energetics of Protein Folding: why proteins fold into stable conformations?.- Introduction: Protein structure, assembly and dynamics.- Protein structural diversity: globular, multidomain and intrinsically unstructured.- The thermodynamic hypothesis of protein folding: Anfinsen’s dogma.- Outlook: The amyloid state.- Protein stability: how is the folded conformation maintained?.- Physical Driving Forces for protein folding and stability.- Measuring protein stability: chemical and thermal denaturation.- Outlook: Hyperstable proteins: lessons from thermophiles and knotted proteins.- Protein Folding Kinetics and mechanisms: how do proteins fold?.- The Levinthal paradox and folding funnels.- Folding intermediates and the molten globule state.- The nucleation mechanism of protein folding.- A survey on experimental methods:  time-resolved methods and the chevron plot.- Computational analysis of folding kinetics: go-model and full atomistic analysis.- Outlook: protein folding in the cell.- Protein misfolding and aggregation.- Protein aggregation, aggresomes and inclusion bodies.- Mechanisms of amyloid formation: aggregates, protofibrilis and fibrils .- Mechanisms and analysis of fibril formation .- Evolutionary adaptations to prevent aggregation (gatekeeping residues).- Outlook: protein folding and disease.

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