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Urea Transporters

  • Book
  • © 2014

Overview

Editors:
  1. Baoxue Yang

    1. School of Basic Medical Sciences, Department of Pharmacology, Peking University, Beijing, China

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    You can also search for this editor in PubMed   Google Scholar

  2. Jeff M. Sands

    1. Renal Division, Department of Medicine and Department of Physiology, Emory University School of Medicine, Atlanta, USA

    View editor publications

    You can also search for this editor in PubMed   Google Scholar

  • Covers research advances in the study of urea transporter over the past 20 years
  • Provides a systematic and comprehensive insight into urea transporters
  • Introduces clinical and pharmaceutical aspects of urea and urea transporters, linking the bench work to the bedside
  • Written by experts in this field
  • Includes supplementary material: sn.pub/extras

Part of the book series: Subcellular Biochemistry (SCBI, volume 73)

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Table of contents (14 chapters)

  1. Front Matter

    Pages i-x
    Download chapter PDF

  2. Overview and Historical Perspective

    • Baoxue Yang, Jeff M. Sands
    Pages 1-5

  3. Urea

    • Hongkai Wang, Jianhua Ran, Tao Jiang
    Pages 7-29

  4. Mathematical Modeling of Urea Transport in the Kidney

    • Anita T. Layton
    Pages 31-43

  5. Genes and Proteins of Urea Transporters

    • Jeff M. Sands, Mitsi A. Blount
    Pages 45-63

  6. Structure of Urea Transporters

    • Elena J. Levin, Ming Zhou
    Pages 65-78

  7. Expression of Urea Transporters and Their Regulation

    • Janet D. Klein
    Pages 79-107

  8. Biochemical Properties of Urea Transporters

    • Guangping Chen
    Pages 109-126

  9. Transport Characteristics of Urea Transporter-B

    • Baoxue Yang
    Pages 127-135

  10. Urea Transporter Knockout Mice and Their Renal Phenotypes

    • Robert A. Fenton, Baoxue Yang
    Pages 137-152

  11. Extrarenal Phenotypes of the UT-B Knockout Mouse

    • Baoxue Yang, Xin Li, Lirong Guo, Yan Meng, Zixun Dong, Xuejian Zhao
    Pages 153-164

  12. Small-Molecule Inhibitors of Urea Transporters

    • Alan S. Verkman, Cristina Esteva-Font, Onur Cil, Marc O. Anderson, Fei Li, Min Li et al.
    Pages 165-177

  13. Clinical Aspects of Urea Transporters

    • Jianhua Ran, Hongkai Wang, Tinghai Hu
    Pages 179-191

  14. Active Urea Transport in Lower Vertebrates and Mammals

    • Lise Bankir
    Pages 193-226

  15. Urea Transport Mediated by Aquaporin Water Channel Proteins

    • Chunling Li, Weidong Wang
    Pages 227-265
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Keywords

About this book

The mechanisms and physiological functions of urea transporters across biological membranes are subjects of long-standing interests. Although urea represents roughly 40% of all urinary solutes in normal human urine, the handling of urea in the tissues has been largely neglected in the past and few clinical or experimental studies now report data on urea. Most recent physiological text books include chapters on water and electrolyte physiology but no chapter on urea. Our aim in writing this book is to stimulate further research in new directions by providing novel and provocative insights into the further mechanisms and physiological significance of urea metabolism and transport in mammals. This book offers a state-of-the-art report on recent discoveries concerning urea transport and where the field is going. It mainly focuses on advances made over the past 20 years on the biophysics, genetics, protein structure, molecular biology, physiology, pathophysiology and pharmacology of urea transport in mammalian cell membranes. It will help graduate students and researchers to get an overall picture of mammalian urea transporters and may also yield benefits for pharmaceutical companies with regard to drug discovery based on the urea transporter. Baoxue Yang is a professor and vice chairman of the Department of Pharmacology, Peking University. He is also an adjunct professor of Jilin University and a visiting professor of Northeast Normal University. Prof. Yang has been researching urea transporters for nearly 20 years and has published more than 70 original research articles in this field.

Editors and Affiliations

  • School of Basic Medical Sciences, Department of Pharmacology, Peking University, Beijing, China

    Baoxue Yang

  • Renal Division, Department of Medicine and Department of Physiology, Emory University School of Medicine, Atlanta, USA

    Jeff M. Sands

About the editors

Baoxue Yang is a professor and vice chairman of Department of Pharmacology, Peking University. He is also an adjunct professor of Jilin University and a visiting professor of Northeast Normal University. Prof. Yang has been studying on urea transporter for nearly 20 years and published more than 70 original research articles in this field.

Jeff M. Sands is the Juha P. Kokko Professor of Medicine and Physiology, Director of the Renal Division, and Executive Vice-Chair of the Department of Medicine at Emory Universtiy School of Medicine. Dr. Sands' research focuses on urea transport proteins and the urine concentrating mechanisms.

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