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Homocysteine in Protein Structure/Function and Human Disease

Chemical Biology of Homocysteine-containing Proteins

  • Book
  • © 2013

Overview

Authors:
  1. Hieronim Jakubowski

    1. Department of Microbiology and Molecular, UMDNJ-New Jersey Medical School, International Center for Public Health, NEWARK, USA

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  • Gives new aspects in protein chemistry - protein structure/function modifications by homocysteine

  • Presents relationship between homocysteinylated proteins, human disease and life span

  • Covers description of procedures of detection, quantification and study of proteins by homocysteine

  • Discusses utility of homocysteine-containing proteins as diagnostic markers?

  • Includes supplementary material: sn.pub/extras

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Table of contents (7 chapters)

  1. Front Matter

    Pages i-xiii
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  2. Introduction

    • Hieronim Jakubowski
    Pages 1-5

  3. An Overview of Homocysteine Metabolism

    • Hieronim Jakubowski
    Pages 7-18

  4. Homocysteine-Thiolactone

    • Hieronim Jakubowski
    Pages 19-53

  5. Discoveries of Protein S- and N-Homocysteinylation

    • Hieronim Jakubowski
    Pages 55-57

  6. N-Homocysteinyl-Proteins

    • Hieronim Jakubowski
    Pages 59-105

  7. Pathophysiological Consequences of Protein N-Homocysteinylation

    • Hieronim Jakubowski
    Pages 107-119

  8. S-Homocysteinylated Proteins

    • Hieronim Jakubowski
    Pages 121-135

  9. Back Matter

    Pages 137-166
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Keywords

About this book

Excess of homocysteine, a product of the metabolism of the essential amino acid methionine, is associated with poor health, is linked to heart and brain diseases in general human populations, and accelerates mortality in heart disease patients. Neurological and cardiovascular abnormalities occur in patients with severe genetic hyperhomocysteinemia and lead to premature death due to vascular complications. Although it is considered a non-protein amino acid, studies over the past dozen years have discovered mechanisms by which homocysteine becomes a component of proteins. Homocysteine-containing proteins lose their normal biological function and become auto-immunogenic and pro-thrombotic. In this book, the author, a pioneer and a leading contributor to the field, describes up-to date studies of the biological chemistry of homocysteine-containing proteins, as well as pathological consequences and clinical implications of their formation. This is a comprehensive account of the broad range of basic science and medical implications of homocysteine-containing proteins for health and disease. ​

Authors and Affiliations

  • Department of Microbiology and Molecular, UMDNJ-New Jersey Medical School, International Center for Public Health, NEWARK, USA

    Hieronim Jakubowski

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