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Chemical Biology of Nucleic Acids

Fundamentals and Clinical Applications

  • Book
  • © 2014

Overview

Editors:
  1. Volker A. Erdmann

    1. Institute of Chemistry/Biochemistry, Free University Berlin, Berlin, Germany

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  2. Wojciech T. Markiewicz

    1. Institute of Bioorganic Chemistry, Polish Academy of Sciences, Poznan, Poland

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    You can also search for this editor in PubMed   Google Scholar

  3. Jan Barciszewski

    1. Institute of Bioorganic Chemistry, Polish Academy of Sciences, Poznan, Poland

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    You can also search for this editor in PubMed   Google Scholar

  • Detailed and comprehensive overview of the various different RNA species
  • Bench to bedside approach
  • Written by leading authorities in the field
  • Includes supplementary material: sn.pub/extras

Part of the book series: RNA Technologies (RNATECHN)

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Table of contents (29 chapters)

  1. Front Matter

    Pages i-xi
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  2. RNA as Major Components in Chemical Evolvable Systems

    • Peter Strazewski
    Pages 1-24

  3. How the Early Genetic Code Was Established?: Inference from the Analysis of Extant Animal Mitochondrial Decoding Systems

    • Kimitsuna Watanabe, Shin-ichi Yokobori
    Pages 25-40

  4. Isomerization of RNA Phosphodiester Linkages

    • Harri Lönnberg
    Pages 41-56

  5. Effects of Ionic Liquid and Liposomes on the Structure, Stability, and Function of Nucleic Acids

    • Naoki Sugimoto
    Pages 57-74

  6. Oxidative Damage on RNA Nucleobases

    • Pascal A. Küpfer, Christian J. Leumann
    Pages 75-94

  7. Use of FRET to Study Dynamics of DNA Replication

    • Philip Nevin, Penny J. Beuning
    Pages 95-111

  8. Design, Characterization, and Application of Imidazopyridopyrimidine:Naphthyridine Base-Pairing Motifs Consisting of Four Hydrogen Bonds

    • Noriaki Minakawa, Akira Matsuda
    Pages 113-129

  9. Creation of Unnatural Base Pair Systems Toward New DNA/RNA Biotechnologies

    • Michiko Kimoto, Ichiro Hirao
    Pages 131-148

  10. Flexible Nucleobase Analogues: Novel Tools for Exploring Nucleic Acids

    • Sarah C. Zimmermann, Katherine L. Seley-Radtke
    Pages 149-165

  11. Sequence-Selective Recognition of Double-Stranded RNA

    • Eriks Rozners
    Pages 167-180

  12. Determining Transient Nucleic Acid Structures by NMR

    • Jeetender Chugh
    Pages 181-198

  13. Diastereomer-Specific Repertoire of 7′R- or 7′S-Me-Carba-Locked Nucleic Acids (cLNAs) in Antisense Oligo/RNA Duplexes and Engineering of Physico-chemical and Enzymological Properties

    • Qing Li, Oleksandr Plashkevych, Ram Shankar Upadhayaya, Sachin Gangadhar Deshpande, Andras Földesi, Jyoti Chattopadhyaya
    Pages 199-226

  14. Challenges and Opportunities for Oligonucleotide-Based Therapeutics by Antisense and RNA Interference Mechanisms

    • Ramon Eritja, Montserrat Terrazas, Santiago Grijalvo, Anna Aviñó, Adele Alagia, Sónia Pérez-Rentero et al.
    Pages 227-242

  15. Progress in Chemically Modified Nucleic Acid Aptamers

    • Masayasu Kuwahara
    Pages 243-270

  16. Aptamers as Molecular Smugglers

    • Eileen Magbanua, Ulrich Hahn
    Pages 271-292

  17. Biochemical Aspects of Subcellular RNA Transport and Localization

    • Diana Bauermeister, Maike Claußen, Tomas Pieler
    Pages 293-308

  18. Small Size, Big Impact: Bacterial Functional Nucleic Acids and Their Applications

    • Wendy W. K. Mok, Simon A. McManus, Yingfu Li
    Pages 309-323

  19. Towards Defined DNA and RNA Delivery Vehicles Using Nucleic Acid Nanotechnology

    • Anders Hauge Okholm, David Schaffert, Jørgen Kjems
    Pages 325-345

  20. Targeted Editing of Therapeutic Genes Using DNA-Based Transcriptional Activators: Scope and Challenges

    • Ganesh N. Pandian, Hiroshi Sugiyama
    Pages 347-365
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Keywords

About this book

This volume contains 29 engrossing chapters contributed by worldwide, leading research groups in the field of chemical biology. Topics include pre-biology; the establishment of the genetic code; isomerization of RNA; damage of nucleobases in RNA; the dynamic structure of nucleic acids and their analogs in DNA replication, extra- and intra-cellular transport; molecular crowding by the use of ionic liquids; new technologies enabling the modification of gene expression via editing of therapeutic genes; the use of riboswitches; the modification of mRNA cap regions; new approaches to detect appropriately modified RNAs with EPR spectroscopy and the use of parallel and high-throughput techniques for the analysis of the structure and new functions of nucleic acids. This volume discusses how chemistry can add new frontiers to the field of nucleic acids in molecular medicine, biotechnology and nanotechnology and is not only an invaluable source of information to chemists, biochemists and life scientists but will also stimulate future research.

Editors and Affiliations

  • Institute of Chemistry/Biochemistry, Free University Berlin, Berlin, Germany

    Volker A. Erdmann

  • Institute of Bioorganic Chemistry, Polish Academy of Sciences, Poznan, Poland

    Wojciech T. Markiewicz, Jan Barciszewski

Bibliographic Information

  • Book Title: Chemical Biology of Nucleic Acids

  • Book Subtitle: Fundamentals and Clinical Applications

  • Editors: Volker A. Erdmann, Wojciech T. Markiewicz, Jan Barciszewski

  • Series Title: RNA Technologies

  • DOI: https://doi.org/10.1007/978-3-642-54452-1

  • Publisher: Springer Berlin, Heidelberg

  • eBook Packages: Biomedical and Life Sciences, Biomedical and Life Sciences (R0)

  • Copyright Information: Springer-Verlag Berlin Heidelberg 2014

  • Hardcover ISBN: 978-3-642-54451-4Published: 06 May 2014

  • Softcover ISBN: 978-3-662-51324-8Published: 23 August 2016

  • eBook ISBN: 978-3-642-54452-1Published: 22 April 2014

  • Series ISSN: 2197-9731

  • Series E-ISSN: 2197-9758

  • Edition Number: 1

  • Number of Pages: XI, 599

  • Number of Illustrations: 147 b/w illustrations, 84 illustrations in colour

  • Topics: Nucleic Acid Chemistry, Molecular Medicine, Human Genetics

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