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Discusses applications of IDPs and IDPRs as potential drug targets
Includes an introduction to the concept of protein intrinsic disorder
Provides an overview of current literature in the field
In this brief, Vladimir Uversky discusses the paradigm-shifting phenomenon of intrinsically disordered proteins (IDPs) and hybrid proteins containing ordered domains and functional IDP regions (IDPRs). Beginning with an introduction to the concept of protein intrinsic disorder, Uversky then goes on to describe the peculiar amino acid sequences of IDPs, their structural heterogeneity, typical functions and disorder-based binding modes. In the final sections, Uversky discusses IDPs in human diseases and as potential drug targets. This volume provides a snapshot to researchers entering the field as well as providing a current overview for more experienced scientists in related areas.
Content Level »Research
Keywords »Binding Promiscuity - Conformational Ensemble - Intrinsically Disordered Protein - Protein Folding - Protein Function - Structural Heterogeneity