Progress in Drug Research / Fortschritte der Arzneimittelforschung / Progrès des recherches pharmaceutiques

1. Front Matter

   Pages 1-5

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2. Foreword

   • E. Jucker

   Pages 6-7

3. The use of quantum chemical methods to study molecular mechanisms of drug action

   • H.-D. Höltje, M. Hense, S. Marrer, E. Maurhofer

   Pages 9-74

4. Systemic cancer therapy: Four decades of progress and some personal perspectives

   • Charles L. Vogel

   Pages 75-162

5. Oligosaccharide chains of glycoproteins

   • Y. T. Pan, Alan D. Elbein

   Pages 163-207

6. Pharmacology of migraine

   • Neil H. Raskin

   Pages 209-230

7. Natriuretic hormones

   • William J. Wechter, Elaine J. Benaksas

   Pages 231-260

8. Barbiturates and the GABAA receptor complex

   • Paul A. Saunders, I. K. Ho

   Pages 261-286

9. Bioactive peptide analogs: In vivo and in vitro production

   • Horst Kleinkauf, Hans von Doehren

   Pages 287-317

10. Computer-assisted structure — Antileukemic activity analysis of purines and their aza and deaza analogs

    • V. L. Narayanan, Mohamed Nasr, Kenneth D. Paull

    Pages 319-341

11. Medicinal chemistry: A support or a driving force in drug research?

    • George deStevens

    Pages 343-358

12. Steroidogenic capacity in the adrenal cortex and its regulation

    • Michael R. Waterman, Evan R. Simpson

    Pages 359-381

13. Neuroimmune axis as a basis of therapy in Alzheimer’s disease

    • Vijendra K. Singh

    Pages 383-393

14. Fungal metabolites and Chinese herbal medicine as immunostimulants

    • Eric J. Lien

    Pages 395-420

15. Progress in the chemotherapy of leprosy: Status, issues and prospects

    • Robert H. Gelber

    Pages 421-445

16. Present status of Leishmaniasis

    • Anita Mukherjee, Manju Seth, A. P. Bhaduri

    Pages 447-490

17. Back Matter

    Pages 491-547

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Today's drug research is an extremely complex process which, apart from chemistry, pharmacology, toxicology and preclinical trials, in­ cludes a variety of sciences such as biotechnology, biochemistry, im­ munology, physics, biology and even computer sciences. The Table of Contents of the present volume demonstrates this situation and makes it evident that the individual researcher cannot possibly hope to keep abreast of all aspects of modern drug research. In this re­ spect, the series of monographs "Progress in Drug Research" pro­ vides valuable help and assistance. Those who simply wish to remain informed of the latest trends and developments in drug research can use the 34 volumes so far available as a source of almost encyclo­ pedic character. Researchers actively engaged in the various scientific fields forming the entity of drug research can benefit from the wealth of knowledge and experience of the respective authors, and they will be assisted in their endeavour to discover new pharmaceutical agents. Moreover, the extensive bibliographies of the individual reviews provide an invaluable overview of the literature most pertinent to today's drug research. I should like to thank all the authors for their willingness to prepare the reviews and for sharing their insights and experience with the readers. Thanks are also due to Mrs L. Koechlin, H.-P. Thiir and A. Gomm of Birkhauser Publishers for their valuable help in the pre­ paration of this volume.

• Arzneimittel
• Arzneimittelforschung
• biochemistry
• biology
• biotechnology
• chemistry
• clinical trial
• drug
• drug discovery
• drug research
• pharmacology
• research
• toxicology

• Basel, Switzerland

  Ernst Jucker

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