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Gamma-Glutamyl Transpeptidases

Structure and Function

  • Book
  • © 2013

Overview

Authors:
  1. Immacolata Castellano

    1. SZN, Stazione Zoologica Anton Dohrn, Naples, Italy

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    You can also search for this author in PubMed   Google Scholar

  2. Antonello Merlino

    1. , Dep. of Chemical Sciences, University of Naples, Naples, Italy

    View author publications

    You can also search for this author in PubMed   Google Scholar

  • Comprehensive, up-to-date overview
  • Includes supplementary material: sn.pub/extras

Part of the book series: SpringerBriefs in Biochemistry and Molecular Biology (BRIEFSBIOCHEM)

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Table of contents (1 chapter)

  1. Front Matter

    Pages i-viii
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  2. Gamma-Glutamyl Transpeptidases: Structure and Function

    • Immacolata Castellano, Antonello Merlino
    Pages 1-57
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Keywords

About this book

 Gamma-Glutamyl Transpeptidases (γ-GTs) are members of the N-terminal nucleophile hydrolase superfamily, enzymes that cleave the γ-glutamyl amide bond of glutathione to liberate cysteinylglycine. The released γ-glutamyl group can be transferred to water (hydrolysis) or to amino acids or short peptides (transpeptidation). γ-GT plays a key role in the gamma glutamyl cycle by regulating the cellular levels of the antioxidant glutathione, hence it is a critical enzyme in maintaining cellular redox homeostasis.γ-GT is upregulated during inflammation and in several human tumors, and it is involved in many physiological disorders related to oxidative stress, such as Parkinson’s disease and diabetes. Furthermore, this enzyme is used as a marker of liver disease and cancer. This book covers current knowledge about the structure-function relationship of γ-GTs and gives information about applications of γ-GTs in different fields ranging from clinical biochemistry to biotechnology and biomedicine.​

Authors and Affiliations

  • SZN, Stazione Zoologica Anton Dohrn, Naples, Italy

    Immacolata Castellano

  • , Dep. of Chemical Sciences, University of Naples, Naples, Italy

    Antonello Merlino

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