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Single-molecule Studies of Proteins

  • Book
  • © 2013

Overview

Editors:
  1. Andres F. Oberhauser

    1. , Neuroscience and Cell Biology, University of Texas Medical Branch, Galveston, USA

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  • Explores sophisticated advances in powerful new analytical, computational, and imaging methods
  • Cover ways in which single-molecule methods can be applied to studying protein function
  • Lays the foundation for additional research to monitor processes within living cells at high resolution and define the complex networks of interactions which regulate cellular function
  • Includes supplementary material: sn.pub/extras

Part of the book series: Biophysics for the Life Sciences (BIOPHYS, volume 2)

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Table of contents (9 chapters)

  1. Front Matter

    Pages i-xiii
    Download chapter PDF

  2. Nanomechanics of Proteins, Both Folded and Disordered

    • Rubén Hervás, Albert Galera-Prat, Àngel Gómez-Sicilia, Fernando Losada-Urzáiz, María del Carmen Fernández, Débora Fernández-Bravo et al.
    Pages 1-47

  3. Force Spectroscopy and Recognition Imaging of Cells from the Immune System

    • Bianca L. Bozna, Memed Duman, Peter Hinterdorfer
    Pages 49-75

  4. Catch Bonds of Integrin/Ligand Interactions

    • Cheng Zhu, Wei Chen
    Pages 77-96

  5. AFM Visualization of Protein–DNA Interactions

    • Yuri L. Lyubchenko
    Pages 97-117

  6. Nanovisualization of Proteins in Action Using High-Speed AFM

    • Takayuki Uchihashi, Noriyuki Kodera, Toshio Ando
    Pages 119-147

  7. Enzyme Catalysis at the Single-Molecule Level

    • Raul Perez-Jimenez, Jorge Alegre-Cebollada
    Pages 149-168

  8. Single-Molecule Studies of Amyloidogenic Proteins

    • Miklós S. Z. Kellermayer, Árpád Karsai, Ünige Murvai, Szilvia Erdélyi-Bótor, József Kardos, Ricardo H. Pires
    Pages 169-210

  9. Stretching and Imaging Individual Proteins on Live Cells Using Atomic Force Microscopy

    • David Alsteens, Yves F. Dufrêne
    Pages 211-233

  10. Individual Proteins Under Mechanical Stress: Lessons from Theory and Computer Simulations

    • Dmitrii E. Makarov
    Pages 235-268

  11. Back Matter

    Pages 269-274
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About this book

In Single Molecule Studies of Proteins, expert researchers discuss the successful application of single-molecule techniques to a wide range of biological events, such as the imaging and mapping of cell surface receptors, the analysis of the unfolding and folding pathways of single proteins, the analysis interaction forces between biomolecules, the study of enzyme catalysis or the visualization of molecular motors in action. The chapters are aimed at established investigators and post-doctoral researchers in the life sciences wanting to pursue research in the various areas in which single-molecule approaches are important; this volume also remains accessible to advanced graduate students seeking similar research goals.

Editors and Affiliations

  • , Neuroscience and Cell Biology, University of Texas Medical Branch, Galveston, USA

    Andres F. Oberhauser

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