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Systems Biology of Parkinson's Disease

  • Book
  • © 2012

Overview

Editors:
  1. Peter Wellstead

    1. , Hamilton Institute, National University of Ireland, Maynooth, Maynooth, Ireland

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  2. Mathieu Cloutier

    1. Ecole Polytechnique de Montreal, Montreal, Canada

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  • Shows how methods of systems biology have the potential to accelerate research into diseases like Parkinson's disease

  • Takes a translational approach to systems biology concentrating on disease

  • Chapters offer a concerted effort to develop a systems view of Parkinson's disease

  • Includes supplementary material: sn.pub/extras

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Table of contents (8 chapters)

  1. Front Matter

    Pages i-xvi
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  2. Imaging of Dopaminergic Neurons and the Implications for Parkinson’s Disease

    • Wakoto Matsuda
    Pages 1-17

  3. Modelling and Simulation of Brain Energy Metabolism: Energy and Parkinson’s Disease

    • Peter Wellstead, Mathieu Cloutier
    Pages 19-38

  4. Systems Biology of Aging: Opportunities for Parkinson’s Disease

    • Andres Kriete
    Pages 39-55

  5. Mitochondrion- and Endoplasmic Reticulum-Induced SK Channel Dysregulation as a Potential Origin of the Selective Neurodegeneration in Parkinson’s Disease

    • Guillaume Drion, Vincent Seutin, Rodolphe Sepulchre
    Pages 57-79

  6. Energetics of Ion Transport in Dopaminergic Substantia nigra Neurons

    • Febe Francis, Míriam R. García, Richard H. Middleton
    Pages 81-109

  7. Real-Time In Vivo Sensing of Neurochemicals

    • Fiachra B. Bolger, Niall J. Finnerty, John P. Lowry
    Pages 111-129

  8. Modeling Protein and Oxidative Metabolism in Parkinson’s Disease

    • Mathieu Cloutier, Peter Wellstead
    Pages 131-150

  9. Mathematical Models of Dopamine Metabolism in Parkinson’s Disease

    • Zhen Qi, Gary W. Miller, Eberhard O. Voit
    Pages 151-171

  10. Back Matter

    Pages 173-176
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Keywords

About this book

The Systems Biology of Parkinson’s Disease will be underpinned by new measurement techniques. This is particularly true of the pathology of Parkinson's Disease, where recent developments in brain imaging have offered new insights into the morphology of dopaminergic neurons that have profound implications for the special vulnerability and role of this class of neurons.

Reviews

From the reviews:

“This book is based on the fascinating concept of applying systems biology … to understand how things work and apply this approach to the study of Parkinson’s disease. … The book is intended for Parkinson’s disease specialists and researchers, and it is best suited for researchers. It is well written by credible authorities in the field. … The book accomplishes its main goals without question. This is a novel approach to an important clinical condition.” (Joseph I. Sirven, Doody’s Review Service, September, 2012)

Editors and Affiliations

  • , Hamilton Institute, National University of Ireland, Maynooth, Maynooth, Ireland

    Peter Wellstead

  • Ecole Polytechnique de Montreal, Montreal, Canada

    Mathieu Cloutier

Bibliographic Information

  • Book Title: Systems Biology of Parkinson's Disease

  • Editors: Peter Wellstead, Mathieu Cloutier

  • DOI: https://doi.org/10.1007/978-1-4614-3411-5

  • Publisher: Springer New York, NY

  • eBook Packages: Biomedical and Life Sciences, Biomedical and Life Sciences (R0)

  • Copyright Information: Springer Science+Business Media New York 2012

  • Hardcover ISBN: 978-1-4614-3410-8Published: 09 May 2012

  • Softcover ISBN: 978-1-4939-0126-5Published: 11 June 2014

  • eBook ISBN: 978-1-4614-3411-5Published: 08 May 2012

  • Edition Number: 1

  • Number of Pages: XVI, 176

  • Topics: Systems Biology, Neurosciences, Biomedicine general

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