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BetaSys

Systems Biology of Regulated Exocytosis in Pancreatic ß-Cells

Series: Systems Biology

Booß-Bavnbek, B., Klösgen, B., Larsen, J., Pociot, F., Renström, E. (Eds.)

2011, XX, 556 p. With online files/update.

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  • Uses the example of regulated exocytosis in pancreatic β-cells, and its relevance to diabetes, to illustrate the major concepts of systems biology, its methods and applications
  • In using a focused approach here by picking one outlook, the topic of Systems Biology is made more accessible
  • Systems Biology is a fast moving field, but the work presented here emphasizes the principal aspects of the field, making this a tool for on-going research
The insulin secreting β-cell is one of the most specialized cell types with diverse and multi-functional components (genes, gene products, organelles and metabolites) and a multitude of regulatory strategies in response to internal and environmental signals. This book looks at the technological advances that make simultaneous detection of thousands of biological variables possible; at a substantial variety of mathematical models and numerical simulations that aim to explain major aspects of the β-cell function; and at the challenge to formulate a comprehensive and robust model of the main networks of the underlying biochemical and physical processes for diagnostic and therapeutic use.

Content Level » Research

Related subjects » Human Genetics - Internal Medicine - Systems Biology and Bioinformatics

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