Peptide Science — Present and Future

1. Front Matter

   Pages i-xxxxvi

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2. Plenary lectures

   1. From big molecules to smaller ones

      • J.A. Wells, B. C. Cunningham, A. Braisted, S. Atwell, W. Delano, M. Ultsch et al.

      Pages 1-5

   2. Directions for solving the remaining problems in the synthesis of large peptides

      • S. Sakakibara

      Pages 6-14

3. General lectures

   1. Peptide science: past, present and future

      • D. Brandenburg

      Pages 15-20

   2. Quo vadis? Where is peptide chemistry headed?

      • T. Shiba

      Pages 21-25

4. Peptide mimetics and de novo design

   1. Designing peptidomimetic antagonists for peptide receptors: topochemical differences of agonists and antagonists

      • V. J. Hruby, S. Liao, G. Han, G. Bonner, M. Shenderovich, J. Slaninova et al.

      Pages 26-29

   2. Self-assembling homopolymeric peptide tapes in aqueous solution

      • A. Aggeli, M. Bell, A. Strong, S. Radford, N. Boden

      Pages 30-33

   3. Peptides containing nonnatural amino acids with functional side groups

      • M. Sisido

      Pages 34-38

   4. Active carbonates of N-protected amino alcohols for synthesis of carbamate pseudopeptides

      • J. B. HalstrØm

      Pages 39-40

   5. Convenient one-pot synthesis of cystine-containing peptides from protected peptidyl resins and its application to the synthesis of bifunctional anti-HIV compounds

      • H. Tamamura, T. Ishihara, H. Oyake, A. Otaka, N. Fujii

      Pages 41-43

   6. Stereoselective synthesis of two type (E)-alkene dipeptide isosteres from a single substrate of β-aziridinyl- α,β-enoate

      • H. Tamamura, M. Yamashita, H. Muramatsu, T. Ibuka, A. Otaka, N. Fujii

      Pages 44-46

   7. Design and synthesis of conformationally constrained dipeptide containing the α-fluoroglycine residue

      • Y. Takeuchi, K. Kirihara, M. Kamezaki, N. Shibata

      Pages 47-48

   8. Screening of peptidomimetic tyrosine kinase inhibitors for inducing programmed cell death

      • G. Kéri, L. ôrfi, F. Hollósy, T. Vántus, J. érchegyi, M. Idei et al.

      Pages 49-51

   9. Molecular assembly of helix peptides vertically oriented on gold surface

      • Y. Miura, S. Kimura, Y. Imanishi, J. Umemura

      Pages 52-53

   10. Gramicidin vesicles — self-assembly in water composed of gramicidin A as hydrophobic core of membrane

       • D. -H. Kim, S. Kimura, Y. Imanishi

       Pages 54-56

   11. Design, synthesis, and characterization of a dimeric analog of small globular protein (SGP) in solution and its biological and channel-forming activities

       • T. Kiyota, E. Matsumoto, S. Yamashita, S. Lee, G. Sugihara

       Pages 57-58

   12. Molecular design of cyclic peptides containing a non-natural amino acid: novel synthetic approach to artificial ion channels

       • K. Donowaki, H. Ishida, Y. Inoue, Z. Qi, M. Sokabe, M. Azumano et al.

       Pages 59-60

   13. Structure based design and characterization of exocyclic peptidomimetics that inhibit TNFα binding to its receptor

       • W. Takasaki, Y. Kajino, K. Kajino, M. I. Greene, R. Murali

       Pages 61-63

   14. A three-helix bundle metallopeptide destabilized at an acidic condition

       • K. Suzuki, T. Tanaka

       Pages 64-66

   15. The alamethicin-leucine zipper hybrid peptide: modulation of the assembling of transmembrane peptides through the extramembrane peptide segments

       • S. Futaki, M. Fukuda, M. Niwa

       Pages 67-69

In the late 1980s, Peptide Societies were established in Europe, the United States, and Japan, and more recently, in the Asian and the Pacific Rim regions including Australia, China, and Korea. At the time of the establishment of the American, European and Japanese Peptide Societies, the International Liaison Organizing Committee representing these Peptide Societies, along with the Australian Peptide Society, began discussions for holding international confer ences which would supercede or be held in lieu of the numerous individual meetings, held by the peptide societies of each individual country or region. The representative of the Chinese Peptide Society participated in these discus sion in the International Liaison Organizing Committee at the meeting of the American Peptide Symposium in Nashville, in June 1997. After lengthy discus sions over several years, we agreed to organize and host the International Peptide Symposium in Japan. The First International Peptide Symposium (IPS’97) was held on November 30–December 5, 1997, in Kyoto, and was co sponsored by four Peptide Societies. The attendance at this Symposium was 550 participants, including representatives from 32 different countries. We were very pleased with this outcome and anticipate an even larger attendance for forthcoming Symposia in future years. The revolution and advances in science and technology during the past two decades has caused traditional peptide chemistry to expand to peptide science, spreading from physical science to biology, pharmacology, and medicine.

• Alanin
• Amino acid
• Antigen
• DNA
• Lipid
• Oligosaccharid
• Oxidation
• Rearrangement
• Secondary structure
• biochemistry
• metabolism
• physiology
• primary structure
• proteins
• spectroscopy

• Osaka University, Japan

  Yasutsugu Shimonishi

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