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Provides overview of the diversity and complex evolutionary history of cell stress proteins
This comprehensive volume, written by experts in the field, provides a current understanding of the molecular properties of the heat shock proteins and their roles in health and disease. Cell Stress Proteins includes advances in several aspects of stress protein research, with chapters ranging from basic studies of the role of heat shock proteins in protein folding to reviews examining the breakdown of stress protein regulation during disease. It also provides analysis of the biochemical and molecular properties of heat shock proteins which can be utilized in evaluating their role in human physiology and pathology. Cell Stress Proteins is an ideal book for researchers, clinicians, physicians, and graduate students in the fields of biochemistry, cell biology, microbiology, immunology, and genetics.
Introduction: Heat Shock Proteins—From Drosophila Stress Proteins to Mediators of Human Disease.- Introduction: Heat Shock Proteins—From Drosophila Stress Proteins to Mediators of Human Disease.- Stress Response and Molecular Chaperones.- Biology of the Heat Shock Response and Stress Conditioning.- Bacterial Stress Sensors.- Unfolded Protein Response: Contributions to Development and Disease.- Molecular Mechanisms of Stress Protein Expression.- Genetic Models of HSF Function.- HSF1 and HSP Gene Regulation.- Cellular Stress Proteins.- Small Heat Shock Proteins in Physiological and Stress-Related Processes.- Large Mammalian hsp70 Family Proteins, hsp110 and grp170, and Their Roles in Biology and Cancer Therapy.- Molecular Chaperones and Protein Folding.- Regulation of Hsp70 Function: Hsp40 Co-Chaperones and Nucleotide Exchange Factors.- Protein Disassembly by Hsp40-Hsp70.- Mammalian HSP40/DnaJ Chaperone Proteins in Cytosol.- Role of Molecular Chaperones in Cell Regulation.- FKBP Co-Chaperones in Steroid Receptor Complexes.- Up and Down Regulation of the Stress Response by the Co-Chaperone Ubiquitin Ligase CHIP.- Role of Cdc37 in Protein Kinase Folding.- Intracellular and Extracellular Stress Proteins in Human Disease.- Targeting Hsp90 in Cancer and Neurodegenerative Disease.- gp96 and Tumor Immunity.- Immunoregulatory Activities of Extracellular Stress Proteins.- Heat Shock Proteins and Neurodegenerative Diseases.- Heat Shock Proteins in the Progression of Cancer.