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Protein Tyrosine Phosphatase Control of Metabolism

  • Book
  • © 2013

Overview

Editors:
  1. Kendra K. Bence

    1. Department of Animal Biology, University of Pennsylvania, Philadelphia, USA

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  • Covers the identification of new phosphatases that are involved in metabolic control

  • Includes a review of tissue-specific effects of protein tyrosine phosphatase 1B

  • Book is timely given the growing epidemic of metabolic syndrome, obesity and diabetes

  • Includes supplementary material: sn.pub/extras

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Table of contents (13 chapters)

  1. Front Matter

    Pages i-xi
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  2. Redox Regulation of PTPs in Metabolism: Focus on Assays

    • Yang Xu, Benjamin G. Neel
    Pages 1-26

  3. Quantitative Modeling Approaches for Understanding the Role of Phosphatases in Cell Signaling Regulation: Applications in Metabolism

    • Matthew J. Lazzara
    Pages 27-48

  4. Protein-Tyrosine Phosphatase 1B Substrates and Control of Metabolism

    • Yannan Xi, Fawaz G. Haj
    Pages 49-69

  5. PTP1B and TCPTP in CNS Signaling and Energy Balance

    • Kendra K. Bence, Tony Tiganis
    Pages 71-89

  6. PTP1B in the Periphery: Regulating Insulin Sensitivity and ER Stress

    • Mirela Delibegovic, Nimesh Mody
    Pages 91-105

  7. Role of Protein Tyrosine Phosphatase 1B in Hepatocyte-Specific Insulin and Growth Factor Signaling

    • Águeda González-Rodríguez, Ángela M. Valverde
    Pages 107-127

  8. PTP1B in Obesity-Related Cardiovascular Function

    • Pimonrat Ketsawatsomkron, David W. Stepp, Eric J. Belin de Chantemèle
    Pages 129-145

  9. Role of the SHP2 Protein Tyrosine Phosphatase in Cardiac Metabolism

    • Maria I. Kontaridis, Eleni V. Geladari, Charalampia V. Geladari
    Pages 147-167

  10. Metabolic Effects of Neural and Pancreatic Shp2

    • Zhao He, Sharon S. Zhang, Jianxiu Yu, Gen-Sheng Feng
    Pages 169-186

  11. Protein Tyrosine Phosphatase Epsilon as a Regulator of Body Weight and Glucose Metabolism

    • Ari Elson
    Pages 187-202

  12. The Role of LMPTP in the Metabolic Syndrome

    • Stephanie M. Stanford, Massimo Bottini, Nunzio Bottini
    Pages 203-220

  13. Mitogen-Activated Protein Kinase Phosphatases in Metabolism

    • Ahmed Lawan, Anton M. Bennett
    Pages 221-238

  14. Glycogen Metabolism and Lafora Disease

    • Peter J. Roach, Anna A. DePaoli-Roach
    Pages 239-262

  15. Back Matter

    Pages 263-273
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About this book

Although phosphorylation of proteins on tyrosine is relatively rare compared to phosphorylation on serine or threonine residues, the past two decades of research into PTP function have led to a great appreciation of the critical role PTPs have in regulating basic cellular processes. Among these important roles is the regulation of cellular signaling pathways related to metabolism. This volume contains chapters which highlight many aspects of PTP function in the context of metabolism. Given the growing obesity and diabetes epidemics in the United States and throughout the world, the desire to identify possible therapeutic targets for treatment of these diseases is a high priority. In many ways, PTPs may be attractive drug targets since they are amenable to targeting with small molecules; however many challenges abound in making PTP inhibitors.

Editors and Affiliations

  • Department of Animal Biology, University of Pennsylvania, Philadelphia, USA

    Kendra K. Bence

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