Malaria

1. Front Matter

   Pages i-xi

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2. Introduction

   • Krishna R. Dronamraju

   Pages 1-12

3. J.B.S. Haldane (1892–1964)

   • Krishna R. Dronamraju

   Pages 13-24

4. Removal of Early Parasite Forms from Circulation as a Mechanism of Resistance Against Malaria in Widespread Red Blood Cell Mutations

   • Paolo Arese, Kodjo Ayi, Aleksei Skorokhod, Franco Turrini

   Pages 25-53

5. Clinical, Epidemiological, and Genetic Investigations on Thalassemia and Malaria in Italy

   • Stefano Canali, Gilberto Corbellini

   Pages 55-80

6. Resistance to Antimalarial Drugs: Parasite and Host Genetic Factors

   • Rajeev K. Mehlotra, Peter A. Zimmerman

   Pages 81-124

7. Evolutionary Origins of Human Malaria Parasites

   • Stephen M. Rich, Francisco J. Ayala

   Pages 125-146

8. Vector Genetics in Malaria Control

   • V.P. Sharma

   Pages 147-167

9. The Rate of Mutations of Human Genes

   • J. B. S. Haldane

   Pages 169-174

10. Disease and Evolution

    • J. B. S. Haldane

    Pages 175-187

11. Back Matter

    Pages 189-190

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This book was originally conceived at a conference at the University of Turin in Italy. The conference was organized to examine the so-called “Malaria Hypothesis”, that is to say, the higher fitness of t- lassemia heterozygotes in a malarial environment, and to pay tribute to the proponent of that hypothesis, J.B.S. Haldane. Contributors to this book examine certain genetic and evolutionary aspects of malaria which is a major killer of human populations, especially in Africa and Asia. There were attempts to discredit Haldane’s contribution from two directions: (a) it has been suggested that the “Malaria Hypothesis” was known long before Haldane and that there was nothing original about his idea (Lederberg 1999), and that (b) the hypothesis of heterozygote su- riority was first suggested by the Italian biologist Giuseppe Montalenti who communicated his idea to Haldane (Allison 2004). Surely, both c- not be right. In fact, the evidence presented in this book clearly indicates that both are wrong. Haldane’s malaria hypothesis has stimulated a great deal of research on the genetic, evolutionary and epidemiological aspects of malaria d- ing the last 50 years. It has opened up a whole new chapter in the study of infectious diseases. It deserves serious consideration. For helpful discussions we thank Lucio Luzzatto, Alberto Piazza, Guido Modiano and David Roberts.

• Malaria
• evolution
• infection
• infectious
• infectious disease

From the reviews:

"Malaria focuses on genetic and evolutionary insights into a paradise blamed for the death of a child every 30 s worldwide. … Malaria: Genetic and Evolutionary Aspects will benefit a broad range of medical, scientific, and public health professionals. Besides strengthening our understanding of the evolutionary origins of malaria, the text opens new perspectives into infectious diseases." (Richard A. Stein, American Journal of Physical Anthropology, Vol. 133, 2007)

• Foundation for Genetic Research, Houston, USA

  Krishna R. Dronamraju

• Department of Genetics, Biology and Biochemistry, University of Torino Medical School, Torino, Italy

  Paolo Arese

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