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  • Book
  • © 2014

Management of Castration Resistant Prostate Cancer

  • All chapters are written by experts in their fields
  • Provides up to date guidelines and algorithms for management
  • Provides a concise yet comprehensive summary of the current status of the field

Part of the book series: Current Clinical Urology (CCU)

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Table of contents (23 chapters)

  1. Front Matter

    Pages i-xvi
  2. Castrate-Resistant Prostate Cancer: Clinical and Biological Considerations

    1. Front Matter

      Pages 1-1
    2. Molecular Mechanisms of Prostate Cancer Progression After Castration

      • William G. Nelson, Kenneth J. Pienta
      Pages 31-41
    3. New Imaging Modalities

      • Steve Y. Cho, Seyed S. Dianat, Katarzyna J. Macura
      Pages 43-63
  3. Treatment: The Androgen Receptor Signaling Axis Biology and Therapeutic Opportunities, Systemic Chemotherapy, Immunotherapy, Bone Targeted Approaches and Radiopharmaceuticals

    1. Front Matter

      Pages 65-65
    2. Androgen Receptor Biology in Castration Resistant Prostate Cancer

      • Heather H. Cheng, Bruce Montgomery
      Pages 67-75
    3. The Androgen Receptor as a Therapeutic Target for Castration-Resistant Prostate Cancer

      • Jarett L. Feldman, Dana Rathkopf, Michael J. Morris
      Pages 77-94
    4. Approaches Targeting Androgen Synthesis (CYP 17 Inhibitors)

      • Adam Siegel, Charles J. Ryan
      Pages 95-105
    5. Cytotoxic Chemotherapy (Taxanes and Taxane Combinations)

      • Robert J. van Soest, Ellen S. de Morrée, Cora N. Sternberg, Ronald de Wit
      Pages 107-119
    6. The Emerging Role of Immunotherapy in Castrate-Resistant Prostate Cancer

      • Romualdo Barroso-Sousa, Charles G. Drake
      Pages 121-137
    7. Bone-Targeted Therapy: Rationale and Current Status

      • Benjamin A. Gartrell, Fred Saad
      Pages 139-153
    8. Radium-223 and Other Radiopharmaceuticals in Prostate Cancer

      • Oliver Sartor, Brian Lewis
      Pages 155-163
  4. New Drug Development: Clinical Trials Design in CRPC

    1. Front Matter

      Pages 165-165
    2. Introduction

      • Aurelius Omlin, Carmel Pezaro, Johann S. de Bono
      Pages 167-176
    3. Phase I–II Targeted Treatments

      • Carmel Pezaro, Aurelius Omlin, Johann S. de Bono
      Pages 177-186
    4. Defining Clinical Endpoints in Castration-Resistant Prostate Cancer

      • Jorge A. Garcia, Robert Dreicer
      Pages 187-199
  5. New Drug Development: Specific Targets

    1. Front Matter

      Pages 201-201
    2. Angiogenesis Inhibition in Castration-Resistant Prostate Cancer

      • Daniel J. George, William Kelly, Aaron Mitchell
      Pages 203-231

About this book

This volume provides new data about the molecular biology of CRPC and a review of the definition, staging and prognostic factors that define CRPC. The book features an in depth review of proven therapeutic options, including bone targeted therapies, immunotherapy, chemotherapy and hormonal based therapies. Combination therapy as well as novel targeted approaches presently under investigations are also reviewed. The text provides up to date guidelines and algorithms for the management of CRPC based on international guidelines presently available as well as evidence based medicine.

As a concise yet comprehensive summary of the current status of the field, Management of Castration Resistant Prostate Cancer serves as a very useful resource for physicians and researchers dealing with this challenging malignancy.

Reviews

From the book reviews:

“This volume in the Current Clinical Urology series focuses on the management of castration resistant prostate cancer (CRPC), providing an important reference for medical oncologists, urologists, and radiation oncologists. The authors successfully update the biology and clinical aspects of CRPC management. … This book sets out the most current knowledge about the management of CRPC, a fascinating area in clinical urology. It should be part of the library of any clinician or basic scientist dealing with prostate cancer.” (Jianqing Lin, Doody’s Book Reviews, November, 2014)

Editors and Affiliations

  • Department of Surgery, University of Montreal Hospital Center, Montreal, Canada

    Fred Saad

  • Department of Oncology, The Johns Hopkins University, Baltimore, USA

    Mario A. Eisenberger

About the editors

Fred Saad, MD, FRCS
Professor and Chief of Urology, Director of GU Oncology, University of Montreal Endowed Chair in Prostate Cancer, University of Montreal Hospital Center, Department of Surgery, Division of Urology, Montreal, Quebec, Canada.

Mario A. Eisenberger, MD
R. Dale Hughes Professor of Oncology and Urology, The Johns Hopkins University, Department of Oncology, The Sidney Kimmel Comprehensive Cancer Center, Baltimore, MD, USA.

Bibliographic Information

  • Book Title: Management of Castration Resistant Prostate Cancer

  • Editors: Fred Saad, Mario A. Eisenberger

  • Series Title: Current Clinical Urology

  • DOI: https://doi.org/10.1007/978-1-4939-1176-9

  • Publisher: Humana New York, NY

  • eBook Packages: Medicine, Medicine (R0)

  • Copyright Information: Springer Science+Business Media New York 2014

  • Hardcover ISBN: 978-1-4939-1175-2Published: 21 August 2014

  • eBook ISBN: 978-1-4939-1176-9Published: 20 August 2014

  • Series ISSN: 2197-7194

  • Series E-ISSN: 2197-7208

  • Edition Number: 1

  • Number of Pages: XVI, 337

  • Topics: Urology, Oncology, Interventional Radiology

Buy it now

Buying options

eBook USD 129.00
Price excludes VAT (USA)
  • Available as EPUB and PDF
  • Read on any device
  • Instant download
  • Own it forever
Hardcover Book USD 169.99
Price excludes VAT (USA)
  • Durable hardcover edition
  • Dispatched in 3 to 5 business days
  • Free shipping worldwide - see info

Tax calculation will be finalised at checkout

Other ways to access