The Testis

1. Front Matter

   Pages i-xvii

   PDF

2. Prologue

   1. Front Matter

      Pages 1-1

      PDF

   2. Unlocking the Mysteries of Male Reproductive Function: How Far Have We Come and Where Are We Going?

      • Barry R. Zirkin, Bernard Robaire

      Pages 3-9

   3. Spermatogenesis After the Millennium

      • Norman B. Hecht

      Pages 10-18

3. Testis Development and Differentiation

   1. Front Matter

      Pages 19-19

      PDF

   2. Sry and the Testis: Molecular Pathways of Organogenesis

      • Blanche Capel

      Pages 21-29

   3. MIS Actions in the Developing Testis

      • Mary Min-chin Lee

      Pages 30-42

   4. Regulation of the Differentiation of the Undifferentiated Spermatogonia

      • Dirk G. de Rooij, Bianca H. G. J. Schrans-Stassen, Ans M. M. van Pelt, Gladis A. Shuttlesworth, Marvin L. Meistrich, Masaru Okabe et al.

      Pages 43-54

   5. Regulation of Growth and Survival in the Mammalian Germline

      • Maria P. De Miguel, Mark J. Federspiel, Peter J. Donovan

      Pages 55-70

4. Paracrine and Endocrine Interactions

   1. Front Matter

      Pages 71-71

      PDF

   2. Synthesis, Fate, and Proposed Function of Clusterin (SGP-2) in the Testis

      • Robert W. Bailey, Ann Clark, Elena Lymar, Walter A. Tribley, Michael D. Griswold

      Pages 73-81

   3. HRT for the Aging Male: A Therapy That Has Come of Age?

      • J. Lisa Tenover

      Pages 82-88

   4. Androgen Replacement in Young Men

      • Frederick C. W. Wu

      Pages 89-105

5. Genetics and Cell Biology of Spermatogenesis

   1. Front Matter

      Pages 107-107

      PDF

   2. Developmental Genetics of Spermatogenesis in the Nematode Caenorhabditis elegans

      • Steven W. L’Hernault, Andrew W. Singson

      Pages 109-119

   3. Regulation of Meiosis and Spermatid Differentiation in Drosophila Primary Spermatocytes

      • Ting-Yi Lin, M. Jodeane Pringle, Margaret T. Fuller

      Pages 120-132

   4. HSP70 Chaperones in Spermatogenesis

      • Edward M. Eddy, William D. Willis, Kiyoshi Miki, Chisato Mori

      Pages 133-142

   5. Characterization of the Testicular Histone-Binding Protein, NASP

      • Michael G. O’Rand, Iglika N. Batova, Richard T. Richardson

      Pages 143-150

   6. The Actin-Bundling Protein Espin and Its Role in the Ectoplasmic Specialization

      • James R. Bartles, Lili Zheng, Min Wang, Bin Chen

      Pages 151-160

6. Epididymal Maturation and Fertilization

   1. Front Matter

      Pages 161-161

      PDF

This volume contains the proceedings of the XVth North American Testis Workshop, held in Louisville, Kentucky, April 7 to 10, 1999, to describe current advances in testis biology. The first two chapters provide a useful historical perspective of testis physiology and formulate compelling research questions about important aspects of sperm formation and function. This prologue sets the scene for the remainder of the volume that follows a logical progression, as the title implies, from stem cell to cell function, but that is necessarily preceded by sex determination, the quintessential requirement for there being a testis in the first place. The program for this XVth Testis Workshop evolved from recommenda­ tions of the scientific committee and their advice on the selection of invited speakers. The XVth Testis Workshop has a strong comparative flavor with contributions on worms (Caenorhabditis), flies (Drosophila), and chickens, which are models that permit and thereby reveal the power of genetic analy­ ses of the molecular mechanisms involved in spermatogenesis. A glimpse into the future is provided with information from EST, protein, and genome databases that already have an impact on progress in our understanding of the male germ cell. Although there is heavy emphasis in these chapters on cellular and molecular e,¥ents, database mining and translational profiling relevant to testis function and dysfunction and assisted reproduction tech­ nologies are not overlooked.

• aging
• biology
• cell biology
• chaperone
• development
• fertility
• gene expression
• genes
• genetics
• infertility
• protein
• stem cell
• testis
• therapy

• Department of Biochemistry, Molecular Biology and Cell Biology, Northwestern University, Evanston, USA

  Erwin Goldberg

Policies and ethics