Bisphosphonates and Osteonecrosis of the Jaw: A Multidisciplinary Approach
De Ponte, Francesco Saverio (Ed.)
2012, XIII, 181 p. 98 illus., 76 illus. in color.
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First multidisciplinary text on the subject, by worldwide experts
Update of the latest advances, technical details, and expert advice regarding this subject
Presents multiple designs, explanatory figures on physiopathogenesis, and clinical imaging
Clinical case discussions and practical advice for incorporation into common practice
Bisphosphonates are commonly prescribed to inhibit bone loss in patients with osteoporosis, as well as osteopenia, cancer, and Paget's disease of the bone. Recently, scientific literature has addressed a possible relationship between bisphosphonates and osteonecrosis of the jaw (ONJ). It is important to note that though the risks for developing ONJ are much higher for cancer patients on intravenous bisphosphonate therapy (used to reduce bone pain), the occurrence of ONJ also in patients treated with oral BF for osteoporosis has been also highlighted, though rarely. On the basis of the large use of BF, of their pharmacokinetics, of the systemic and local risk factors, physicians prescribing them and dental surgeons should be well informed on the various aspects of the problem. Aim of this volume is to offer an update on the current status of prevention, and on the current conservative and surgical treatments. The multidisciplinary approach will be very much appreciated by GP’s, the different specialists using bisphosphonates and by dental surgeons.
Content Level »Professional/practitioner
Keywords »bisphosphonates - osteonecrosis - pharmacology - surgery - tumor
Preface-1. Introduction - 2. Pharmacology: Mechanism of Action of Bisphosphonates- 3. Use of Bisphosphonates in Oncology, Hematology and Osteoporosis - 4. Biomorphology in BIONJ: Anatomy and History - 5. Ethiopathogenesis and clinic of BIONJ - 6. Instrumental Diagnosis.- 7. Microbiological Aspects - 8. Prevention and role of Dentist - 9. Conservative Treatment: Oxygen, Ozone and Laser - 10. Minimally Invasive Surgical Treatment - 11. Major Surgery in BIONJ - 12. The future of BIONJ