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Showing the enormous progress that has been made towards the understanding and treatment of neurovascular events
The book contains 48 articles presented at the 11th International Conference on Cerebral Vasospasm held in Cincinnati, Ohio, USA, in July 2011. This collection of papers represents a cross-section of the enormous progress that has been made towards a thorough understanding and effective treatment of neurovascular events following aneurysmal subarachnoid hemorrhage, including cerebral vasospasm. It is of interest to clinicians who wish to apply state-of-the-art knowledge to their management of this devastating condition and to basic scientists wishing to expand their understanding of cerebrovascular and neural pathophysiology related to subarachnoid hemorrhage.
CLINICAL TRIALS AND DILEMMAS:History and definition of delayed cerebral ischemia. - Clinical, transcranial Doppler ultrasound, radiological features and prognostic significance of delayed cerebral ischemia. - Identifying patient report outcomes relevant to aneurysmal subarachnoid hemorrhage follow-up. - Global cerebral atrophy after subarachnoid hemorrhage: A possible marker of acute brain injury and assessment of its impact on outcome. - Protein biomarkers in patients with subarachnoid hemorrhage, vasospasm and delayed ischemic neurological deficits. - Randomized trial of clazosentan, an endothelin receptor antagonist, in patients with aneurysmal subarachnoid hemorrhage undergoing surgical clipping (CONSCIOUS-2). - Angiographic vasospasm versus cerebral infarction as outcome measures after aneurysmal subarachnoid hemorrhage. - Development of Nicardipine prolonged-release implants after clipping for preventing cerebral vasospasm: From laboratory to clinical trial. - Magnesium sulphate for aneurysmal subarachnoid hemorrhage: Why, how, and current controversy. - Prolonged intravenous infusion of sodium nitrite delivers nitric oxide (NO) in healthy volunteers. – Special article: Proposed mechanism of cerebral vasospasm: Our hypothesis and current topics. - NEUROCRITICAL CARE: Monitoring of cerebral hemodynamics and oxygenation to detect delayed ischemic neurological deficit after aneurysmal subarachnoid hemorrhage: - Usefulness of three dimensional computed tomography to quantify the subarachnoid hemorrhage volume: Prediction of symptomatic vasospasm. - COSBID-M3: A platform for multimodal monitoring, data collection and research in neurocritical care. -Transcranial Doppler as a routine in the treatment of vasospasm following subarachnoid hemorrhage. – Systemic interleukin-6 levels reflect illness course and prognosis of patients with spontaneous nonanueyrsmal subarachnoid hemorrhage. - Beneficial effect of selective intra-arterial infusion of fasudil hydrochloride as a treatment of symptomatic vasospasm following subarachnoid hemorrhage. - SURGICAL AND ENDOVASCULAR MANAGEMENT:Removal of clots in subarachnoid space could reduce the vasospasm after subarachnoid hemorrhage. – Effect of lumbar puncture in patients with neurismal subarachnoid hemorrhage treated microsurgically or endovascularly. – Effect of aneurysm treatment modalities on cerebral vasospasm after neurismal subarachnoid hemorrhage. – Endovascular management of post-hemorrhagic cerebral vasospasm: Indications, technical nuances and results. – The concept of a hybrid operation room: Applications in cerebrovascular surgery. – Computerized occlusion rating of embolized ruptured intracranial aneurysms: Relation to intra- and postinterventional aneurysm rehemorrhage. - SPREADING DEPOLARIZATIONS: Spreading ischemia after aneurismal subarachnoid hemorrhage. – Full-band electrocorticography of spreading depolarizations in patients with neurismal subarachnoid hemorrhage. – Cerebral glucose and spreading depolarization in patients with neurismal subarachnoid hemorrhage. – Evaluation of intracranial electrocorticography recording strips and tissue partial pressure of oxygen and temperature probes for radiofrequency induced heating. – Criteria for the diagnosis of non-infectious and infectious complications after neurismal subarachnoid hemorrhage. – Neurovascular coupling during spreading depolarizations. - NEUROVASCULAR COUPLING AND MICROVASCULATURE: Subarachnoid blood converts neurally evoked vasodilation to vasoconstriction in rat brain cortex. - Impact of subarachnoid hemorrhage on parenchymal arteriolar function. - SAH-induced suppression of voltage-gated K+ (Kv) channel currents in parenchymal arteriolar myocytes involves activation of the HB-EGF/EGFR pathway. - Mechanisms of microthrombosis and microcirculatory constriction after experimental subarachnoid hemorrhage. - Cerebral hemodynamic and metabolic effects of remote ischemic preconditioning in patients with subarachnoid hemorrhage. -Cerebral microvasculature is an early target of subarachnoid hemorrhage. -PRECLINICAL STUDIES: The roles of early brain injury in cerebral vasospasm following subarachnoid hemorrhage: From clinical and scientific aspects. -Matricellular protein: A new player in cerebral vasospasm following subarachnoid hemorrhage. - Role of platelet-derived growth factor in cerebral vasospasm after subarachnoid hemorrhage in rats. - Relevance of animal models of subarachnoid hemorrhage for examining neurobehavioral changes. - Inflammation in subarachnoid hemorrhage and delayed deterioration associated with vasospasm: A review . - Attenuation of cerebral vasospasm following experimental subarachnoid hemorrhage by the bronchodilator KMUP-3. - Pharmacologic reduction of angiographic vasospasm in experimental subarachnoid hemorrhage: Systematic review. - Low-dose lipopolysaccharide injection prior to subarachnoid hemorrhage modulates delayed deterioration associated with vasospasm in subarachnoid hemorrhage. - Statin induced T-lymphocyte modulation and neuroprotection following experimental subarachnoid hemorrhage. - Role of bilirubin oxidation products in the pathophysiology of DIND following SAH. - RISK FACTORS: Association of morphologic and demographic features of intracranial aneurysms with their rupture: A retrospective analysis. - Location, interaction and anticipation of aneurysm formation. - Symptomatic vasospasm in elderly patients with aneurysmal subarachnoid hemorrhage: Comparison with non-elderly patients