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Medication-Related Osteonecrosis of the Jaws

Bisphosphonates, Denosumab, and New Agents

  • Book
  • © 2015

Overview

Editors:
  1. Sven Otto

    1. Department of Oral and Maxillofacial Sur, Ludwig-Maximilians-University of Munich, Munich, Germany

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  • Coverage of all aspects of osteonecrosis of the jaw related to treatment with antiresorptive drugs especially bisphosphonates and denosumab
  • Practical guidelines for students and practitioners
  • First standard textbook to be devoted to this hot topic
  • Includes supplementary material: sn.pub/extras

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Table of contents (20 chapters)

  1. Front Matter

    Pages i-viii
    Download chapter PDF

  2. Pharmacological Aspects of Antiresorptive Drugs: Bisphosphonates and Denosumab

    • Reiner Bartl, Emmo von Tresckow
    Pages 1-15

  3. Bisphosphonate and Denosumab Therapy: Fields of Application

    • Cornelia Then, Emmo von Tresckow, Reiner Bartl, Fuat S. Oduncu
    Pages 17-26

  4. Risk Factors for Medication-Related Osteonecrosis of the Jaw

    • Tae-Geon Kwon
    Pages 27-42

  5. Definition, Clinical Features and Staging of Medication-Related Osteonecrosis of the Jaw

    • Sven Otto, Tae-Geon Kwon, Alexandre Th. Assaf
    Pages 43-54

  6. Epidemiology of Medication-Related Osteonecrosis of the Jaw

    • Towy Sorel Lazarovici, Tal Yoffe
    Pages 55-61

  7. Imaging Modalities and Characteristics in Medication-Related Osteonecrosis of the Jaw

    • Florian A. Probst, Monika Probst, Sotirios Bisdas
    Pages 63-77

  8. Treatment of Medication-Related Osteonecrosis of the Jaw

    • Christoph Pautke
    Pages 79-91

  9. Local and Microvascular Free Flaps in Patients with Medication-Related Osteonecrosis of the Jaw

    • Thomas Mücke, David A. Mitchell
    Pages 93-101

  10. Adjuvant Treatment Options in the Management of Medication-Related Osteonecrosis of the Jaw

    • Paolo Vescovi, Maddalena Manfredi, Elisabetta Merigo
    Pages 103-109

  11. New and Innovative Treatment Strategies for Medication-Related Osteonecrosis of the Jaw

    • Riham M. Fliefel, Pit J. Voss
    Pages 111-119

  12. Microbiology and Antibiotics in the Context of Medication-Related Osteonecrosis of the Jaw

    • Sebastian Hoefert
    Pages 121-129

  13. Histopathology of Medication-Related Osteonecrosis of the Jaw

    • Risa Chaisuparat, Bruno C. Jham
    Pages 131-137

  14. Pathogenesis of Medication-Related Osteonecrosis of the Jaw

    • Sven Otto, Jose Ignacio Aguirre, Ezher Dayisoylu, Thomas Ziebart
    Pages 139-148

  15. Risk Reduction of Medication-Related Osteonecrosis of the Jaw

    • Noam Yarom, Stefano Fedele
    Pages 149-153

  16. Animal Models of Medication-Related Osteonecrosis of the Jaw

    • Matthew R. Allen
    Pages 155-167

  17. Dental Rehabilitation in Patients Receiving Antiresorptive Drugs

    • Sebastian Hoefert, Feraydoon Sharghi, Eva Engel
    Pages 169-178

  18. Dental Implants in the Context Antiresorptive Drugs and Medication-Related Osteonecrosis of the Jaw

    • Yorck Alexander Zebuhr
    Pages 179-192

  19. Osteonecrosis of the Jaw in Association with Targeted Therapy

    • Matthias Troeltzsch, Markus Troeltzsch, Christoph Pache, Timothy Woodlock
    Pages 193-200

  20. History of Osteonecrosis of the Jaw

    • Sebastian Hoefert, Claudia Sade Hoefert, Martin Widmann
    Pages 201-205
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Keywords

About this book

Osteonecrosis of the jaws is a well-known side-effect of antiresorptive therapy that predominantly occurs in patients suffering from malignant diseases and receiving intravenous administrations of nitrogen-containing bisphosphonates or subcutaneous administrations of denosumab, a monoclonal antibody. Less frequently it may also be observed in patients with osteoporosis who are being treated with these antiresorptive drugs 

This textbook provides detailed, up-to-date information on all aspects of medication-related osteonecrosis of the jaws, including clinical features, pathogenesis, treatment options, and preventive measures. It also explains safe prevention and treatment strategies for patients receiving antiresorptive drugs who require extractions, implant insertions, and other dento-alveolar surgeries. This book will be of major interest for medical and dental students, dentists, and oral and maxillofacial surgeons as well as osteologists and oncologists.

Reviews

“… eine ideale Grundlage für jeden Zahnarzt und Oralchirurgen, um sich über das Krankheitsbild der Kiefernekrose unter antiresorptiven Medikamenten wie Bisphosphonaten und Denosumab zu informieren und sein Wissen bezüglich der zahnärztlichen Behandlung dieser Patienten zu erweitern. ... übersichtlich strukturierte und sehr gut illustrierte Kapitel ... in englischer Sprache erschienen, jedoch auch für Nicht-Muttersprachler sehr verständlich ... Insgesamt kann dieses Buch zahnärztlichen, oralchirurgischen und mund-, kiefer- und gesichtschirurgischen Kollegen nur empfohlen werden.” (Dr. Kleopatra Ziata, in: Bayerisches Zahnärzteblatt BZB, März 2015)

Editors and Affiliations

  • Department of Oral and Maxillofacial Sur, Ludwig-Maximilians-University of Munich, Munich, Germany

    Sven Otto

About the editor

Sven Otto, MD, DDS, is a board-certified specialist in oral and maxillofacial surgery from Germany. He received both his dental degree (2002) and his medical degree (2006) from the University of Leipzig, Germany. Since 2006 he has been a resident at the Department of Oral and Maxillofacial Surgery, Ludwig-Maximilians University of Munich, Germany. One of his major fields of interest is bisphosphonate-related osteonecrosis of the jaw, especially the underlying pathophysiology. He has published numerous articles in leading scientific journals and has lectured nationally and internationally on this subject. In 2011, he was appointed group leader for “Jaw bone and osteonecrosis of the jaw” in the Laboratory for Experimental Surgery and Regenerative Medicine (ExperiMed) of the Ludwig-Maximilians University of Munich.

Bibliographic Information

  • Book Title: Medication-Related Osteonecrosis of the Jaws

  • Book Subtitle: Bisphosphonates, Denosumab, and New Agents

  • Editors: Sven Otto

  • DOI: https://doi.org/10.1007/978-3-662-43733-9

  • Publisher: Springer Berlin, Heidelberg

  • eBook Packages: Medicine, Medicine (R0)

  • Copyright Information: Springer-Verlag Berlin Heidelberg 2015

  • Hardcover ISBN: 978-3-662-43732-2Published: 19 December 2014

  • Softcover ISBN: 978-3-662-52433-6Published: 22 September 2016

  • eBook ISBN: 978-3-662-43733-9Published: 27 November 2014

  • Edition Number: 1

  • Number of Pages: VIII, 220

  • Number of Illustrations: 20 b/w illustrations, 63 illustrations in colour

  • Topics: Oral and Maxillofacial Surgery, Dentistry

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