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  • © 2010

Signaling Pathways in Liver Diseases

  • Completely revised second edition with focus on specific signaling in liver diseases
  • World-renowned contributors provide comprehensive overview on recent progress in hepatology
  • Important source of reference for literature and planning of trails
  • Includes supplementary material: sn.pub/extras

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Table of contents (34 chapters)

  1. Front Matter

    Pages i-xii
  2. The Cell Types and the Matrix

    1. Front Matter

      Pages 2-2
    2. Hepatocytes

      • G. Ramadori, Pierluigi Ramadori
      Pages 3-24
    3. Signaling Pathways in Biliary Epithelial Cells

      • M. Fatima Leite, Viviane A. Andrade, Michael H. Nathanson
      Pages 25-39
    4. Stellate Cells

      • Fabio Marra, Sara Galastri, Sara Aleffi, Massimo Pinzani
      Pages 41-68
    5. Signaling Pathways in Liver Diseases Kupffer Cells

      • Christian J. Steib, Alexander L. Gerbes
      Pages 69-78
    6. Hepatic Sinusoidal Endothelial Cells

      • Robert C. Huebert, Vijay H. Shah
      Pages 79-91
    7. Extracellular Matrix

      • Scott L. Friedman
      Pages 93-104
    8. Platelets: A New Cell Type in Liver Physiology

      • Mickael Lesurtel, Pierre-Alain Clavien
      Pages 105-116
    9. Immune Cell Communication and Signaling Systems in Liver Disease

      • Ricky H. Bhogal, Simon C. Afford
      Pages 117-146
  3. The Pathways

    1. Front Matter

      Pages 148-148
    2. Toll-Like Receptors

      • Gyongyi Szabo, Pranoti Mandrekar
      Pages 149-159
    3. TNF/TNF Receptors

      • Jörn M. Schattenberg, Mark J. Czaja
      Pages 161-177
    4. Fas/FasL

      • Maria Eugenia Guicciardi, Gregory J. Gores
      Pages 179-188
    5. Interferon Signaling

      • Markus H. Heim
      Pages 189-200
    6. NF-κB

      • Tom Luedde, Christian Trautwein
      Pages 201-214
    7. JNKs in liver diseases

      • R. Schwabe
      Pages 215-227
    8. Insulin Pathway

      • Miran Kim, Jack R. Wands
      Pages 229-241
    9. Role of PKB/Akt in Liver Diseases

      • Elena Zhuravleva, Oliver Tschopp, Brian A. Hemmings
      Pages 243-259
    10. Targeting mTOR Signaling Pathways in Liver Disease

      • Hala E. Thomas, Sara C. Kozma
      Pages 261-273

About this book

Signaling Pathways in Liver Diseases, 2nd edition focuses on signaling pathways which are particularly important in liver diseases. Recent progress brought hepatology to new frontiers. The increasing frequency of surgery on steatotic and cirrhotic liver obliges liver surgeons and hepatologists to understand the molecular mechanisms at play in these situations and how they can be influenced. Better comprehension of the cellular mechanisms participating in liver regeneration, hepato-cellular apoptosis and ischemia/reperfusion inquiry is mirrored by a dramatic increase in complexity. The number and scope of publications is intimidating and difficult for busy individuals to extract a coherent framework. This book will serve as a source of information facilitating the reading of the literature and the planning of trials. Translational medicine implies knowledge of the molecular targets for novel therapeutic strategies. It will furthermore stimulate more research and lead to better exchange between the laboratory, the clinical ward and the operation room.

Editors and Affiliations

  • Inselspital, Universität Bern, Bern, Switzerland

    Jean-Francois Dufour

  • Klinik für Viszeral- und, Universitätsspital Zürich, Zürich, Switzerland

    Pierre-Alain Clavien

Bibliographic Information

  • Book Title: Signaling Pathways in Liver Diseases

  • Editors: Jean-Francois Dufour, Pierre-Alain Clavien

  • DOI: https://doi.org/10.1007/978-3-642-00150-5

  • Publisher: Springer Berlin, Heidelberg

  • eBook Packages: Medicine, Medicine (R0)

  • Copyright Information: The Editor(s) (if applicable) and The Author(s), under exclusive license to Springer-Verlag GmbH, DE, part of Springer Nature 2010

  • Hardcover ISBN: 978-3-642-00149-9Due: 18 December 2009

  • Softcover ISBN: 978-3-642-43148-7Published: 13 December 2014

  • eBook ISBN: 978-3-642-00150-5Published: 01 December 2009

  • Edition Number: 2

  • Number of Pages: XV, 526

  • Topics: General Surgery, Hepatology, Gastroenterology, Internal Medicine, Minimally Invasive Surgery, Transplant Surgery

Buy it now

Buying options

eBook USD 139.00
Price excludes VAT (USA)
  • Available as EPUB and PDF
  • Read on any device
  • Instant download
  • Own it forever
Softcover Book USD 249.99
Price excludes VAT (USA)
  • Compact, lightweight edition
  • Dispatched in 3 to 5 business days
  • Free shipping worldwide - see info
Hardcover Book USD 249.99
Price excludes VAT (USA)
  • Durable hardcover edition
  • Dispatched in 3 to 5 business days
  • Free shipping worldwide - see info

Tax calculation will be finalised at checkout

Other ways to access