Membrane Receptors, Channels and Transporters in Pulmonary Circulation

1. Front Matter

   Pages i-xvi

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2. Ion Channels in the Pulmonary Vasculature: Basics and New Findings

   1. Front Matter

      Pages 1-1

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   2. The Role of Ion Channels in Hypoxic Pulmonary Vasoconstriction

      • E. Kenneth Weir, Jésus A. Cabrera, Saswati Mahapatra, Douglas A. Peterson, Zhigang Hong

      Pages 3-14

   3. Two-Pore Domain K+ Channels and Their Role in Chemoreception

      • Keith J. Buckler

      Pages 15-30

   4. Intricate Interaction Between Store-Operated Calcium Entry and Calcium-Activated Chloride Channels in Pulmonary Artery Smooth Muscle Cells

      • Abigail S. Forrest, Jeff E. Angermann, Rajesh Raghunathan, Catherine Lachendro, Iain A. Greenwood, Normand Leblanc

      Pages 31-55

   5. The Role of Intracellular Ion Channels in Regulating Cytoplasmic Calcium in Pulmonary Arterial Smooth Muscle: Which Store and Where?

      • A. Mark Evans

      Pages 57-76

   6. Ca2+ Oscillations Regulate Contraction Of Intrapulmonary Smooth Muscle Cells

      • Michael J. Sanderson, Yan Bai, Jose Perez-Zoghbi

      Pages 77-96

3. TRP Channels in the Pulmonary Vasculature: Basics and New Findings

   1. Front Matter

      Pages 98-98

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   2. Introduction to TRP Channels: Structure, Function, and Regulation

      • Michael Y. Song, Jason X.-J. Yuan

      Pages 99-108

   3. Physiological Functions of Transient Receptor Potential Channels in Pulmonary Arterial Smooth Muscle Cells

      • Xiao-Ru Yang, Mo-Jun Lin, James S. K. Sham

      Pages 109-122

   4. The Contribution of TRPC1 and STIM1 to Capacitative Ca2+ Entry in Pulmonary Artery

      • Lih Chyuan Ng, Judith A. Airey, Joseph R. Hume

      Pages 123-135

   5. Store-Operated Calcium Entry Channels in Pulmonary Endothelium: The Emerging Story of TRPCS and Orai1

      • Donna L. Cioffi, Christina Barry, Troy Stevens

      Pages 137-154

   6. TRPM2 Channel Regulates Endothelial Barrier Function

      • Claudie M. Hecquet, Gias U. Ahmmed, Asrar B. Malik

      Pages 155-167

4. Pathogenic Role of Ion Channels in Pulmonary Vascular Disease

   1. Front Matter

      Pages 170-170

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   2. A Proposed Mitochondrial–Metabolic Mechanism for Initiation and Maintenance of Pulmonary Arterial Hypertension in Fawn-Hooded Rats: The Warburg Model of Pulmonary Arterial Hypertension

      • Jalees Rehman, Stephen L. Archer

      Pages 171-185

   3. The Role of Classical Transient Receptor Potential Channels in the Regulation of Hypoxic Pulmonary Vasoconstriction

      • B. Fuchs, A. Dietrich, T. Gudermann, H. Kalwa, F. Grimminger, N. Weissmann

      Pages 187-200

   4. Developmental Regulation of Oxygen Sensing and Ion Channels in the Pulmonary Vasculature

      • David N. Cornfield

      Pages 201-220

   5. Hypoxic Regulation of Ion Channels and Transporters in Pulmonary Vascular Smooth Muscle

      • Larissa A. Shimoda

      Pages 221-235

   6. CLC-3 Chloride Channels in the Pulmonary Vasculature

      • Joseph R. Hume, Ge-Xin Wang, Jun Yamazaki, Lih Chyuan Ng, Dayue Duan

      Pages 237-247

5. Receptors and Signaling Cascades in Pulmonary Arterial Hypertension

   1. Front Matter

      Pages 250-250

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Membrane Receptors, Channels and Transporters in Pulmonary Circulation is a proceeding of the 2008 Grover Conference (Lost Valley Ranch and Conference Center, Sedalia, Colorado; September 3-7, 2008), which provided a forum for experts in the fields of those receptors, channels and transporters that have been identified as playing key roles in the physiology and pathophysiology of the pulmonary circulation. The book rigorously addresses: i) recent advances in our knowledge of receptors, channels and transporters and their role in regulation of pulmonary vascular function; ii) how modulation of expression and function of receptors, channels and transporters and their interrelationships contribute to the pathogenesis of pulmonary vascular disease; and iii) the therapeutic opportunities that may be revealed by enhancing our understanding of this area. The overall goal was to explore the mechanisms by which specific receptors, channels and transporters contribute to pulmonary vascular function in both health and disease, and how this knowledge may lead to novel interventions in lung dysplasia, pulmonary edema, lung injury, and pulmonary and systemic hypertension to reduce and prevent death from lung disease. Membrane Receptors, Channels and Transporters in Pulmonary Circulation is divided into six parts. Part 1 (Ion Channels in the Pulmonary Vasculature: Basics and New Findings) is designated for basic knowledge and recent findings in the research field of ion channels in pulmonary circulation. There are five chapters in Part I discussing the function, expression, distribution and regulation of various ion channels present in pulmonary vascular smooth muscle cells and how these channels are integrated to regulate intracellular Ca2+ and cell functions. Part II (TRP Channels in the Pulmonary Vasculature: Basics and New Findings) is composed of five chapters that are exclusively designed to discuss the role of a recently identified family of cation channels, transientreceptor potential (TRP) channels, in the regulation of pulmonary vascular tone and arterial structure. Part III (Pathogenic Role of Ion Channels in Pulmonary Vascular Disease) includes four chapters that discuss how abnormal function and expression of various ion channels contribute to changes in cell functions and the development of pulmonary hypertension. Part IV (Receptors and Signaling Cascades in Pulmonary Arterial Hypertension) consists of five chapters devoted to the role of bone morphogenetic protein receptors, Notch receptors, serotonin receptors, Rho kinase and vascular endothelial growth factor receptors in the development of pulmonary arterial hypertension. Part V (Receptors and Transporters: Role in Cell Function and Hypoxic Pulmonary Vasoconstriction) includes four chapters designed to illustrate the potential mechanisms involved in oxygen sensing and hypoxia-induced pulmonary vasoconstriction and hypertension. Part VI (Targeting Ion Channels and Membrane Receptors in Developing Novel Therapeutic Approaches for Pulmonary Vascular Disease) consists five chapters which discuss the translational research involving on membrane receptors, channels and transporters, including their potential as novel drug targets. We hope that Membrane Receptors, Channels and Transporters in Pulmonary Circulation will allow readers to foster new concepts and new collaborations and cooperations among investigators so as to further understand the role of receptors, channels and transporters in lung pathophysiology. The ultimate goal is to identify new mechanisms of disease, as well as new therapeutic targets for pulmonary vascular diseases. An additional outcome should be enhanced understanding of the role of these entities in systemic vascular pathophysiology, since the conference will include researchers and clinicians with interests in both pulmonary and systemic circulations.

• Calcium
• cell
• circulation
• hypertension
• membrane
• physiology
• protein
• regulation
• vascular disease

From the reviews:

“The editors provide a good summary of the conference in this publication of the proceedings. … clearly intended for clinicians with a special interest in the field of pulmonary circulation. Researchers and basic physiologists will find the proceedings very useful for research technology and advancing their knowledge in the field. … Clinicians caring for patients with pulmonary hypertension will find this book very useful … . clinicians will find the book extremely helpful in understanding the pathophysiology of the disease they are treating.” (K. P. Ravikrishnan, Doody’s Review Service, May, 2010)

• Departments of Medicine and Pharmacology, University of Illinois at Chicago, Chicago, USA

  Jason X. -J. Yuan

• Guy’s Hospital Campus, Dept. Physiology, King’s College London, London, United Kingdom

  Jeremy P. T. Ward

Policies and ethics