Growth Factors and Wound Healing

1. Front Matter

   Pages i-xviii

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2. General Concepts

   1. Front Matter

      Pages 1-1

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   2. An Overview of Wound Healing Biology

      • I. Kelman Cohen

      Pages 3-7

   3. Growth Factors and Angiogenesis in Wound Healing

      • Stephanie Rohovsky, Patricia A. D’Amore

      Pages 8-26

   4. The Regulation of Basic Fibroblast Growth Factor (FGF-2) Through Limited Bioavailability

      • Andrew Baird

      Pages 27-36

   5. Cultured Skin Cells for Wound Closure and for Promoting Wound Healing

      • John F. Hansbrough, Hans Oliver Rennekampff

      Pages 37-55

   6. The Growth Hormone Insulin-Like Growth Factor-I Axis

      • Arvind Y. Krishna, Lawrence S. Phillips

      Pages 56-76

3. Role of Nutrients in Wound Healing Responses

   1. Front Matter

      Pages 77-77

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   2. Use of Exogenous Amino Acids in Wound Healing

      • Michael R. Schäffer, Adrian Barbul

      Pages 79-91

   3. Vitamin A-Growth Factor Interactions in Wound Healing

      • Anders E. Ulland, Michael D. Caldwell

      Pages 92-103

   4. Interactions Between Nutrients and Growth Factors in Cellular Anabolism and Tissue Repair

      • Thomas R. Ziegler, Alan B. Puckett, Daniel P. Griffith, John L. Galloway

      Pages 104-147

4. Endogenous Growth Factors and Wound Healing

   1. Front Matter

      Pages 149-149

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   2. Fibroblast Growth Factor Receptors

      • David M. Ornitz, Gabriel Waksman

      Pages 151-174

   3. Arginine and Nitric Oxide (NO) Interactions in the Healing Wound

      • Jorge E. Albina

      Pages 175-185

   4. Endogenous Growth Factors and Nutrients in the Healing Wound

      • Wes J. Arlein, Michael D. Caldwell

      Pages 186-205

   5. Epidermal Growth Factor in Wound Healing: A Model for the Molecular Pathogenesis of Chronic Wounds

      • Roy W. Tarnuzzer, Shawn P. Macauley, Bruce A. Mast, Jane S. Gibson, Michael C. Stacey, Naomi Trengrove et al.

      Pages 206-228

5. Clinical Application of Growth Hormone and IGF-I Therapy

   1. Front Matter

      Pages 229-229

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   2. Growth Hormone Therapy in Human Burn Injury

      • David N. Herndon, Edgar J. Pierre, J. Keith Rose, Karina N. Stokes, Robert E. Barrow

      Pages 231-244

   3. Effects of Exogenous Growth Hormone in Postoperative Immune Function and Other Clinical Outcomes

      • Rafael Vara-Thorbeck, Estrella Ruiz-Requena, José Antonio Guerrero

      Pages 245-259

   4. Effect of Growth Hormone Administration on Colonic Healing and Repair

      • Henrik Christensen

      Pages 260-280

The biology of wound healing and tissue repair are increasingly being defined. At the same time, the availability of recombinant peptide growth factors for clinical investigation has prompted numerous trials of growth factor administration as adjunctive therapy to enhance the rate and quality of acute and chronic wound repair. New basic science information on growth factor function and regulation obtained in the research laboratory is actively being applied in animal studies and in clinical research settings. In addition to studies of surface wounds, an increasing number of investiga­ tions on growth factor administration have focused on healing and repair in nondermal tissues such as the intestinal tract and other organs. While the amount of new information on the molecular biology of growth factor expression, signaling, and function has been exponential in recent years, results of many clinical trials on growth factor administration in wound healing have been disappointing. This maybe due, in part, to the heterogeneity of clinical wounds and the patients who harbor them, less than adequate standardization of care in experimental and control groups, issues related to drug dosing, and inadequate control for important issues relevant to healing such as nutrient intake and underlying nutritional status.   

• growth
• growth factor
• growth hormone
• hormone
• hormone therapy
• insulin-like

• Department of Medicine, Emory University School of Medicine, Atlanta, USA

  Thomas R. Ziegler

• Department of Preclinical Development, PRIZM Pharmaceuticals, San Diego, USA

  Glenn F. Pierce

• Shriners Burns Institute, The University of Texas Medical Branch, Galveston, USA

  David N. Herndon

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