Bone Formation

1. Front Matter

   Pages i-xv

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2. Molecular Regulation of Osteoblast Differentiation

   • Prasanna Bukka, Marc D. McKee, Andrew C. Karaplis

   Pages 1-17

3. In Vitro Regulation of Osteoblast Activity

   • Norman J. Karin, Mary C. Farach-Carson

   Pages 18-43

4. Systemic and Local Regulators of Bone Remodeling

   • Marja M. Hurley, Joseph A. Lorenzo

   Pages 44-70

5. Site-specific Mineralized Matrix Formation by Osteoblasts

   • J. Edward Puzas

   Pages 71-78

6. Biomechanical Aspects of Bone Formation

   • Charles H. Turner

   Pages 79-105

7. Reduced Bone Formation in the Pathogenesis of Bone Fragility

   • T. John Martin, Ego Seeman

   Pages 106-119

8. Diseases of Excess Bone Formation

   • William McLean, Bjorn R. Olsen

   Pages 120-137

9. Targeting the Osteoblast for Prevention and Treatment of Bone Diseases

   • Meinrad Peterlik

   Pages 138-153

10. Back Matter

    Pages 155-160

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Bone research in recent years has generated much new knowledge, in large measure because of the broad public health implications of osteoporosis and related bone disorders. Bone Formation, the first in a series entitled Topics in Bone Biology, evaluates this new information and formulates novel insights and hypotheses within the broad framework of current knowledge. An easy-to handle and to read work, with concise reviews that are extensively referenced, the chapters in this book are written by internationally known authorities. Particular emphasis is on osteoporosis and related disorders of diminished bone formation. Among the general topics treated is a chapter on biomechanical aspects of bone formation, not often considered in relation to diseases of bone formation. The book constitutes essential reading for those entering the field of bone biology and those who wish to become familiar with up-to-date information in a particular area of bone research.

• Calcium
• Farach-Carson
• Pathogene
• Public Health
• biology
• biomechanics
• bone
• metabolism
• osteoporosis
• prevention

From the reviews of the first edition:

"Bone Formation … focuses on the cells that initiate the process of osteogenesis, its regulation, and its disorders. … Experimentalists will appreciate the large amount of cell culture and cell line information made available in the form of extensive tables not readily available elsewhere. … This fundamental science book gives a clear view of the most recent knowledge in research on bone formation. It is presented in a way that makes it easily accessible to an orthopedic surgeon … ." (Claude Karger, European Journal of Orthopaedic Surgery & Traumatology, Vol. 14 (4), 2004)

• Department of BioStructure and Function, Department of Pharmacology, University of Connecticut Health Center, Farmington, USA

  Felix Bronner

• Department of Biological Sciences, University of Delaware, Newark, USA

  Mary C. Farach-Carson

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