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Medicine - Rheumatology | Ankylosing spondylitis and Klebsiella

Ankylosing spondylitis and Klebsiella

Ebringer, Alan

2013, XX, 256 p. 89 illus., 86 illus. in color.

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  • Ankylosing spondylitis and Klebsiella is a handy and informative text on the cause of Ankylosing spondylitis
  • Contains full color illustrations and depicts the microbe Klebsiella’s action on the body
  • Ankylosing spondylitis and Klebsiella is a valuable information resource which contains all of the latest research on the subject making it accessible to patients, research institutions, pharmaceutical firms, universities, health professionals and the general public
  • Contains descriptions of antibodies to Klebsiella in AS patients from 15 different countries

Ankylosing spondylitis and Klebsiella is a comprehensive and informative text on the cause of Ankylosing spondylitis. Ankylosing spondylitis (AS) is a condition which affects 20 million people worldwide and is likely caused or initiated by a bowel infection from Klebsiella bacteria.

 

When a patient is infected by Klebsiella bacteria, his or her immune system will make antibodies against all the antigens or molecules found in the microbe. Because some of the bacterial antigens resemble self tissues, the anti-bacterial antibodies will attack not only the bacteria but also the self tissues such as the joints and the cells having the same HLA molecules, which is how the disease AS starts.  This is the concept of molecular similarity or “molecular mimicry” which previously has been found to work in two other autoimmune diseases; rheumatic fever and rheumatoid arthritis.

 

The first paper on this subject was published in 1976 and since then over 100 papers on rheumatological topics have been published, from Prof Ebringer’s group, at the Division of Life Sciences, King’s College in London, UK.

 

The relevant information from these papers is extracted and presented in this book format making it accessible to health professionals, research institutions, pharmaceutical companies and universities and the general public.

 

Content Level » Professional/practitioner

Keywords » Ankylosing spondylitis - Arthritis - Orthopedics - Rheumatology

Related subjects » Rheumatology

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