CURED I - LENT Late Effects of Cancer Treatment on Normal Tissues

1. Front Matter

   Pages I-XXII

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2. Radiation (and Medical) Biosurveillance

   • Melissa M. Hudson, Wendy Landier, Smita Bhatia, Kevin C. Oeffinger, Charles Sklar, Anna Meadows et al.

   Pages 1-9

3. Medical Countermeasures to Radiation Injury

   • C. Norman Coleman

   Pages 11-17

4. Ionizing Radiation and the Endothelium

   • Luis Felipe L. -G. Fajardo

   Pages 19-22

5. Inflammation and Cell Adhesion Molecules are Involved in Radiation-Induced Lung Injury

   • Christopher D. Willey, Dennis E. Hallahan

   Pages 23-30

6. Volume Effects in Radiation Damage to Rat Lung

   • Richard P. Hill, Mohammed A. Khan, Aimee R. Langan, Ivan W. T. Yeung, Jake Van Dyk

   Pages 31-36

7. The Role of Imaging in the Study of Radiation-Induced Normal Tissue Injury

   • Zafer Kocak, Lalitha Shankar, Daniel C. Sullivan, Lawrence B. Marks

   Pages 37-45

8. Screening for Cardiovascular Disease in Survivors of Thoracic Radiation

   • M. Jacob Adams, Robert G. Prosnitz, Louis S. Constine, Lawrence B. Marks, Steven E. Lipshultz

   Pages 47-59

9. Hypoxia-Mediated Chronic Normal Tissue Injury

   • Mitchell Steven Anscher, Zeljko Vujaskovic

   Pages 61-67

10. Prevention and Treatment of Radiation Injuries

    • Eric P. Cohen, Melissa M. Joines, John E. Moulder

    Pages 69-76

11. Second Malignancies as a Consequence of Radiation Therapy

    • Eric J. Hall, David J. Brenner

    Pages 77-81

12. Using Quality of Life Information to Rationally

    • Moyed Miften, Olivier Gayou, David S. Parda, Robert Prosnitz, Lawrence B. Marks

    Pages 83-89

13. Cancer-Related Fatigue as a Late Effect:

    • Gary R. Morrow, Joseph A. Roscoe, Maralyn E. Kaufman, Christopher Bole, Colmar Figueroa-Moseley, Maarten Hofman et al.

    Pages 91-98

14. Normal Tissue TNM Toxicity Taxonomy

    • Philip Rubin

    Pages 99-107

15. Cancer Survivorship Research:

    • Noreen M. Aziz

    Pages 109-130

16. Back Matter

    Pages 131-143

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The rapid advances in radiation oncology, radiation biology, and radiation therapy physics have led to an accumulation of information on the interactions of radiation with other therapeutic modalities, such as the wide array of chemotherapeutic agents being employed in combination with radiation therapy, as well as the multiple biologic response modi? ers that are being used in combination with radiation therapy. It is now recognized that they have a signi? cant impact on normal tissue toxicities. The radiation doses customarily deemed safe on the basis of past experience have now, when combined with other modalities, led to severe late effects in different vital organs. The previously de? ned radiation tolerance dosages remain as valuable guides, but their applicability has changed signi? cantly. The emphasis is now placed on the volume of the organ irradiated, as well as the dose being used. New constructs rel- ing global (whole organ) and focal (partial volume) injury as a function of the dose volume histogram emerge as a signi? cant predictor of late effects on normal tissues. There are now mathematical models such as the model on standard dose, time–dose factors, and accumulated radiation effects that have been supplanted by linear-q- dratic equations using the alpha/beta ratio and its clinical applicability to normal tissue complications. This volume presents contemporary data relating to late effects on normal tissues.

• Fatigue
• TNM
• TNM staging system
• cancer
• cancer treatment
• cell
• imaging
• inflammation
• pathology
• physiology
• prevention
• radiation
• radiation damage
• radiotherapy
• screening
• Radiaton Oncology
• surgical oncology

From the reviews:

"This book provides a basic science understanding of the processes behind the side effects of radiation. … is appropriate for residents, clinicians, radiobiologists, and medical physicists as it addresses the fundamentals necessary for a firm understanding of radiation sequelae. … The color pictures, graphs, diagrams, and tables beautifully illustrate the main concepts of each chapter. … Chapters outline the guidelines and models for researchers and clinicians … . should be in the library of every radiation oncology department." (Ann Pittier, Doody’s Review Service, August, 2008)

• Department of Radiation Oncology, University of Rochester School of Medicine and Dentistry, Rochester, USA

  Philip Rubin, Paul Okunieff

• Department of Radiation Oncology, Departments of Radiation Oncology and Pediatrics, University of Rochester School of Medicine and Dentistry, Rochester, USA

  Louis S. Constine

• Department of Radiation Oncology, Duke University Medical Center, Durham, USA

  Lawrence B. Marks

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