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Atypical Antipsychotics

  • Book
  • © 2000

Overview

Editors:
  1. Bart A. Ellenbroek

    1. Dept. of Psychoneuropharmacology, University of Nijmegen, Nijmegen, The Netherlands

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  2. Alexander R. Cools

    1. Dept. of Psychoneuropharmacology, University of Nijmegen, Nijmegen, The Netherlands

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    You can also search for this editor in PubMed   Google Scholar

Part of the book series: Milestones in Drug Therapy (MDT)

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Table of contents (11 chapters)

  1. Front Matter

    Pages I-XI
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  2. A general introduction

    1. Front Matter

      Pages 1-1
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    2. Introduction to schizophrenia

      • Peter F. Liddle
      Pages 3-17

    3. From first to second generation antipsychotics

      • John L. Waddington, John F. Quinn
      Pages 19-33

    4. Animal models for schizophrenia: an introduction

      • Bart A. Ellenbroek, Alexander R. Cools
      Pages 35-53

  3. The preclinical evaluation of atypical antipsychotics

    1. Front Matter

      Pages 55-55
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    2. Receptor profile of antipsychotics

      • JosĂ©e E. Leysen
      Pages 57-81

    3. Regional selectivity of antipsychotic drugs

      • Bart A. Ellenbroek, Alexander R. Cools
      Pages 83-98

    4. Screening models for antipsychotic drugs

      • Jørn Arnt
      Pages 99-119

    5. Simulation models for schizophrenia

      • Bart A. Ellenbroek, Frank Sams-Dodd, Alexander R. Cools
      Pages 121-142

  4. The clinical evaluation of atypical antipsychotics

    1. Front Matter

      Pages 143-143
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    2. Clozapine: the first atypical antipsychotic

      • Dieter Naber, Christian Haasen, Christian Perro
      Pages 145-162

    3. Dopamine receptor subtypes and schizophrenia: a clinical perspective

      • Johan A. Den Boer, Jakob Korf
      Pages 163-190

    4. Multireceptor atypical antipsychotic drugs

      • Herbert Y. Meltzer
      Pages 191-213

    5. New discoveries in the development of antipsychotics with novel mechanisms of action: beyond the atypical antipsychotics with serotonin dopamine antagonism

      • Stephen M. Stahl, Darius K. Shayegan
      Pages 215-232

  5. Back Matter

    Pages 233-236
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Keywords

About this book

The introduction of chlorpromazine in 1953, and haloperidol in 1958, into clinical practice dramatically altered the therapy of schizophrenic patients. Although representing by no means a cure for this severe psychiatric ill­ ness, it allowed, for the first time, to adequately control the severe hallu­ cinations and delusional beliefs which prevent these patients from leading a more or less independent life. Indeed these antipsychotics (and the many congeners that were to follow) significantly reduced the number ofchronic schizophrenic inpatients in psychiatric clinics all over the world. However soon after their introduction it became clear that, like all other available drugs, antipsychotics were by no means miracle drugs. In fact, two major problems appeared. First, the antipsychotics had very little effect on the so-called negative or defect symptoms, like social isolation, apathy and anhedonia, and secondly virtually all antipsychotics produced a number of side-effects, of which the neurological (often called extra­ pyramidal) side-effects were the most troublesome. Especially the tardive dyskinesia, which occurred in about 15 to 20% of the patients after pro­ longed treatment, represented a major problem in the treatment of schizo­ phrenic patients.

Editors and Affiliations

  • Dept. of Psychoneuropharmacology, University of Nijmegen, Nijmegen, The Netherlands

    Bart A. Ellenbroek, Alexander R. Cools

Bibliographic Information

  • Book Title: Atypical Antipsychotics

  • Editors: Bart A. Ellenbroek, Alexander R. Cools

  • Series Title: Milestones in Drug Therapy

  • DOI: https://doi.org/10.1007/978-3-0348-8448-8

  • Publisher: Birkhäuser Basel

  • eBook Packages: Springer Book Archive

  • Copyright Information: Springer Basel AG 2000

  • Hardcover ISBN: 978-3-7643-5948-5Published: 01 January 2000

  • Softcover ISBN: 978-3-0348-9571-2Published: 24 October 2012

  • eBook ISBN: 978-3-0348-8448-8Published: 06 December 2012

  • Series ISSN: 2296-6056

  • Series E-ISSN: 2296-6064

  • Edition Number: 1

  • Number of Pages: XI, 236

  • Topics: Psychiatry, Pharmacology/Toxicology, Neurology

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