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Medicine - Pathology | Histological Typing of Tumours of the Exocrine Pancreas

Histological Typing of Tumours of the Exocrine Pancreas

In Collaboration with Pathologists in 7 Countries

Klöppel, G., Solcia, E., Longnecker, D.S., Capella, C., SOBIN, L.

Originally published by WHO, Geneva, 1978

2nd ed., XI, 61 pp. 60 figs. in color, 3 tabs.

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  • About this book

This is a histological classification of tumours and tumour-like lesions of the exocrine pancreas which also includes those tu­ mours showing a mixture of exocrine and endocrine elements. The classification is based principally on standard microscopic observations, but whenever indicated it incorporates diagnosti­ cally valuable immunohistological findings. In addition, the most important immunohistological findings which are helpful in cat­ egorizing pancreatic tumours are summarised in Table 1. The major guideline of this classification scheme is the group­ ing of the pancreatic exocrine tumours according to their biologi­ cal behaviour. Thus, the neoplasms are broadly divided into benign (adenoma) and malignant tumours (carcinoma). How­ ever, in recent years we have learned that this division is not a sharp but rather a gradual transition. We therefore added a third group which we call "tumours of uncertain malignant potential" representing a borderline category analogous to that recognized for some ovarian tumours. This group includes mucinous cystic tumour, intraductal papillary-mucinous tumour and solid­ pseudopapillary tumour. These neoplasms are defined by the grade of dysplasia and/or potential to become malignant. Mucinous cystic tumours of uncertain malignant potential, for instance, exhibit moderate epithelial dysplasia, but do not show severe dysplasia/carcinoma in situ changes, nor carcinomatous invasion of the cyst wall or the adjacent pancreatic tissue. Solid­ pseudopapillary tumour has a benign looking histological ap­ pearance, but metastases may occur. Biologically, all these neoplasms are primarily slow-growing lesions and have an excel­ lent prognosis when adequately treated by complete resection.

Content Level » Research

Keywords » Classification - Exocrine Tumours - Exokrine Tumoren - Histological Typing - Histologische Typierung - Klassifikation - Pancreas - Pankreas

Related subjects » Internal Medicine - Pathology

Table of contents 

Histological Classification of Tumours of the Exocrine Pancreas.- Definitions and Explanatory Notes.- Epithelial Tumours.- Nonepithelial Tumours.- Secondary Tumours.- Tumour-like Lesions.- Illustrations.

Distribution rights 

Distribution rights for Japan: EBS, Tokyo

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