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First book to deal with this emerging group of proteases
Comprehensive review of the current state of research on I-CLiPs
Contributions by authors recognized as leaders in their fields
Easy-to-read descriptive text
Latest information concerning the roles that these I-CLiPs play in biology and disease
Authors Nigel M. Hooper and Otto von Guericke, world leaders in protease research, offer a detailed overview of proteases. Specifically, the authors have written the first book that focuses on recent data stemming from the structural determination of intramembrane-cleaving proteases (I-CLiPs). You get the latest findings concerning the various roles that these proteases play in biology and disease.
In recent years, a growing number of proteases have been identified that catalyze peptide bond hydrolysis in the plane of the cellular membrane. These I-CLiPs are involved in a diverse range of cellular processes, including cell regulation, signaling, quorum sensing, protein processing, lipid metabolism, and the unfolded protein response. As the authors demonstrate, some I-CLiPs play critical roles in diseases such as Alzheimer’s and viral infection.
In short, this book provides an update on an emerging group of proteases that may provide the key to understanding and finding a cure for a number of human diseases.
Chapter 1: THE SITE-2 PROTEASE AT TEN, Robert B. Rawson and Wei-ping Li; Chapter 2: SIGNAL PEPTIDE PEPTIDASES, Todd E. Golde, Criag Zwizinski, Andrew Nyborg; Chapter 3: GXGD-TYPE INTRAMEMBRANE PROTEASES, Harald Steiner, Christian Haass; Chapter 4: RHOMBOID INTRAMEMBRANE SERINE PROTEASES, SINISA URBAN; Chapter 5: PROTEASES OF THE RHOMBOID FAMILY IN THE YEAST SACCHAROMYCES CEREVISIAE, Elke Pratje; Chapter 6: y-SECRETASE AND ALZHEIMER’S DISEASE, Michael S. Wolfe; Chapter 7: y-SECRETASE MEDIATED PROTEOLYSIS: AT THE CUTTING EDGE OF NOTCH SIGNALING, Ma. Xenia G. Ilagan, Dilip Chandu and Raphael Kopan; Index.