Liver Pathology and Alcohol

1. Front Matter

   Pages i-xii

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2. Alcohol and Hepatic Iron Homeostasis

   • Barry J. Potter

   Pages 1-60

3. The Pathogenesis of Inflammation in Alcoholic Liver Disease

   • F. Joseph Roll

   Pages 61-89

4. Liver Cell Membrane Adaptation to Chronic Alcohol Consumption

   • Hagai Rottenberg

   Pages 91-115

5. The Effect of Prenatal Alcohol Exposure on γ-Glutamyl Transpeptidase

   • Edward Reyes

   Pages 117-132

6. Free Radicals and Alcohol Liver Injury

   • Lester A. Reinke, Paul B. McCay

   Pages 133-168

7. Effects of Ethanol on Glutathione Metabolism

   • Mack C. Mitchell, David S. Raiford, Ariane Mallat

   Pages 169-194

8. Liver Cancer

   • Siraj I. Mufti

   Pages 195-219

9. Alcohol and Hepatic Protein Modification

   • Renee C. Lin, Lawrence Lumeng

   Pages 221-239

10. Fatty Acid Ethyl Esters, Alcohol, and Liver Changes

    • Puran S. Bora, Louis G. Lange

    Pages 241-257

11. Ethanol, Lipoprotein Metabolism, and Fatty Liver

    • M. R. Lakshman, Stuart J. Chirtel, Pradeep Ghosh

    Pages 259-285

12. Effect of Ethanol on Splanchnic Blood Flow

    • Edward T. Knych

    Pages 287-307

13. Interaction of Ethanol and the Glucocorticoids

    • Rolf F. Kletzien

    Pages 309-323

14. Genetic and Dietary Control of Alcohol Degradation in Drosophila

    • Billy W. Geer, Robert R. Miller Jr., Pieter W. H. Heinstra

    Pages 325-373

15. Human Liver Alcohol Dehydrogenase Gene Expression

    • Gregg Duester

    Pages 375-402

16. Influence of Ethanol on Functional and Biochemical Characteristics of Skeletal Muscle

    • William E. Sonntag, Rhonda L. Boyd, Anselm D’Costa, Charles R. Breese

    Pages 403-423

17. Alcohol and Liver Damage

    • Thomas M. Soranno, Lester G. Sultatos

    Pages 425-440

18. Polymorphisms of Alcohol and Aldehyde Dehydrogenases and Their Significance for Alcohol Liver Diseases

    • Akira Yoshida, Akitaka Shibuya

    Pages 441-466

19. Effects of Alcohol and Cocaine Abuse on the Antioxidant Systems, Nutritional Status, and Liver Damage

    • Olalekan E. Odeleye, Ronald R. Watson

    Pages 467-511

20. Caffeine Metabolism

    • Charles P. Denaro, Neal L. Benowitz

    Pages 513-539

Alcohol and other drugs of abuse are major contributing factors to liver disease and its pathology. Alcoholic cirrhosis causes thousands of deaths each year in the United States, and encourages liver replacement. A better understanding of the mechanisms of liver pathology will significantly aid basic researchers and physicians in treating and preventing liver damage. This book is designed especially for those researchers wishing to understand alcoholic liver disease. Therefore the role of alcohol in changing nutrition and its nutritional effects on liver disease are reviewed. The generation of free radicals during alcohol use has been found to be an important cause of membrane changes, of cancer development, and of lipid alterations-and thus of liver pathology. In addition to alcohol, other drugs of abuse, including morphine, cocaine, marijuana, and caffeine have also been shown to be significant contributors to liver pathology. The prevalence of drug and alcohol use and abuse today means that liver disease will continue as a major social and medical problem. The explanation of its biological origins cannot fail to help us better understand and treat the disease in the years to come.

• cancer
• cell
• liver
• liver disease
• liver transplantation
• pathogenesis
• transplantation

...the techniques which have been used, the emphasis on free radicals and damage produced by them, are of general pathological interest and this book would certainly not be out of place in a pathology library.-Journal of Medical Microbiology

• University of Arizona, Tucson, USA

  Ronald R. Watson

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