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Medicine - Pathology | Progress in Alzheimer’s and Parkinson’s Diseases

Progress in Alzheimer’s and Parkinson’s Diseases

Proceedings of the Fourth International Conference held in Eilat, Israel, May 18-23, 1997

Fisher, Abraham, Hanin, Israel, Yoshinda, Mitsuo (Eds.)

Softcover reprint of the original 1st ed. 1998, XXIII, 888 p.

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This book represents the fourth ina series of international conferences related to Alzheimer's (AD) and Parkinson's (PO) diseases. The first one took place in EHat, Israel in 1985; the second in Kyoto, Japan, in 1989; and the third in Chicago, IL, USA in 1993. This book incorporates the proceedings of the Fourth International Conference on Pro­ gress in Alzheimer's and Parkinson's Diseases, held in EHat, Israel, on May 18-23, 1997. This Conference was the 41st in the series of annual OHOLO Conferences sponsored by the Israel Institute for Biological Research (IIBR). It was also conducted under the aus­ pices of the Alzheimer's Association Ronald and Nancy Reagan Research Institute, USA. The Conference was attended by 550 participants from 28 countries, representing a broad spectrum of research interests; and included a well-balanced representation from aca­ demia, clinical institutions and pharmaceutical industry. The four-and-one-half day meeting served as an excellent medium for surveying the current preclinical and clinical develop­ ments in AD, PO, and other related disorders. The scientific program was divided into 24 oral sessions and daily poster sessions. The conference culminated in a round table discus­ sion. There were 122 talks and 161 posters. This book incorporates a combination of both.

Content Level » Research

Keywords » Alzheimer - Parkinson - dopamine - neurons - transplantation

Related subjects » Pathology - Pharmacology & Toxicology

Table of contents 

Pathology in Alzheimer's Disease: General: 1. The Pathogenesis of Alzheimer's Disease; R.D. Terry. 2. Molecular and Cellular Abnormalities of Tau in Early Alzheimer's Disease; P. Davis, et al. Apoliprotein E: 3. ApoE and Memory in Alzheimer's Disease; H.S. Soininen, P.J. Riekkinen, Sr. 4. Divergent Metabolism of Apolipoproteins E3 and E4 by Cells; R.E. Pitas, et al. 5. APP, ApoE, and Presenilin Transgenics: Toward a Genetic Model of Alzheimer's Disease; L. Pradier, et al. Apoptosis; Oxidative Stress; Amyloids, Inflammation and Other Defects: 8. Apoptosis in Alzheimer's Disease: Inductive Agents and Antioxidant Protective Factors; C.W. Cotman, C.J. Pike. 9. Membrane Constituencies and Receptor Subtype Contribute to Age-Related Increases in Vulnerability to Oxidative Stress: Implications for Neurodegenerative Disease; J.A. Joseph, et al. 10. Mitochondrial Dysfunction and Alzheimer's Disease; S.S. Ghosh, et al. 11. Mitochondrial Dysfunction in Parkinson's Disease: Potential Applications for Cybrid Modeling of the Disease; R.H. Swerdlow, et al. Amyloid Aggregation: 27. Amyloid-beta Hypothesis of Alzheimer's Disease; M.S. Shearman. 28. Discovery and Characterization of Peptidoorganic Inhibitors of Amyloid beta-Peptide Polymerization; M.A. Findeis, S.M. Molineaux. 29. Anthracyclines and Amyloidosis; C. Post, et al. 30. The Amino Terminus of the beta-Amyloid Peptide Contains an Essential Epitope for Maintaining Its Solubility; B. Solomon, et al. 31. Animal Models of Amyloid Aggregation and Deposition; R. Kisilevsky Tau in Alzheimer's Disease: 32. The Conformations of Tau Protein and Its Aggregation into Alzheimers Paired Helical Filaments; E. Mandelkow, et al. Alzheimer's Disease/Parkinsons's Disease and Related Disorders: Clinical and Etiological Aspects: 37. Different Cognitive Profiles on Memory Tests in Parkinson's Disease and Alzheimer's Disease; R.F. Allegri, et al. Parkinson's Disease&endash;Etiology, Genetics, Treatment: 56. Genetic Aspects of Parkinson's Disease; Y. Mizuno, et al. Cholinergic Strategies in Alzheimer's and Parkinson's Disease: 64. The Rationale for Development of Cholinergic Therapies in AD; A. Enz, P.T. Francis. Alzheimer's Disease&endash;Muscarinic Treatment and Therapy&endash;beta-Amyloids: 70. APP Localization and Trafficking in the Central Nervouse System; J.D. Buxbaum, et al. Cholinesterase Inhibitors for Treatment of Alzheimer's Disease: 75. Crystallographic Studies on Complexes of Acetylcholinesterase with the Natural Cholinesterase Inhibitors Fasciculin and Huperzine A; I. Silman, et al. Neurotrophic Factor Therapy&endash;Neuroprotection, Neurotransplantation and Other Treatment Strategies: 86. Functional Effects of GDNF on Dopamine Neurons in Animal Models of Parkinson's Disease; A.F. Hoffman, et al. Animal Models in Alzheimer's and Parkinson's Diseases: 93. Age Dependence of Muscarinic Plasticity in the Rat Hippocampus; J.M. Auerbach, M. Segal. Diagnostic Too

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