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Neuroprotection and Regeneration of the Spinal Cord

  • Book
  • © 2014

Overview

Editors:
  1. Kenzo Uchida

    1. Dept of Orthop & Rehabilit Med, University of Fukui Faculty of Medical Sciences, Yoshida-gun, Japan

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  2. Masaya Nakamura

    1. Department of Orthopaedic Surgery, Keio University School of Medicine, Tokyo, Japan

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  3. Hiroshi Ozawa

    1. Department of Orthopaedic Surgery, Tohoku University Graduate School of Medicine, Sendai, Japan

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  4. Shinsuke Katoh

    1. Department of Orthopedic Surgery, Faculty of Medicine The University of Tokushima, Tokushima, Japan

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  5. Yoshiaki Toyama

    1. Department of Orthopaedic Surgery, Keio University School of Medicine, Tokyo, Japan

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  • Extensively outlines the latest bench research in spinal cord injury

  • Discusses neuroprotective and novel regenerative techniques for the spinal cord

  • Includes advances in clinical settings

  • Includes supplementary material: sn.pub/extras

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Table of contents (32 chapters)

  1. Front Matter

    Pages i-x
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  2. Pathologies of Spinal Cord Injury

    1. Front Matter

      Pages 1-1
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    2. The Mechanism Behind Functional Recovery After the Incomplete Spinal Cord Injury

      • Seiji Okada
      Pages 3-10

    3. Microenvironment Within the Injured Spinal Cord Focusing on IL-6

      • Masaya Nakamura
      Pages 11-18

    4. Autophagy in Spinal Cord Injury: Pathogenic Roles and Therapeutic Implications

      • Haruo Kanno, Hiroshi Ozawa
      Pages 19-30

    5. The Role of the Endoplasmic Reticulum Stress Response in Neural Apoptosis of the Injured Spinal Cord

      • Masahiko Watanabe, Hiroyuki Katoh, Masahiro Kuroiwa, Takeshi Imai, Kaori Suyama, Daisuke Matsuyama et al.
      Pages 31-41

    6. Roles of Microglia in Spinal Cord Injury

      • Tadanori Ogata, Tadao Morino, Hideki Horiuchi, Hiromasa Miura
      Pages 43-57

  3. Pathologies of Chronic Compressive Spinal Cord

    1. Front Matter

      Pages 59-59
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    2. Biomechanics of the Spinal Cord and the Pia Mater

      • Hiroshi Ozawa, Takeo Matsumoto, Toshiro Ohashi, Masaaki Sato
      Pages 61-74

    3. Biomechanical Analysis of Compressive Myelopathy: The Influence of Morthometry of the Spinal Cord

      • Norihiro Nishida, Tsukasa Kanchiku, Toshihiko Taguchi
      Pages 75-82

    4. Morphologic Change and Glial Response to Unilateral Spinal Cord Compression

      • Hiroshi Ozawa, Jianwu Zhao
      Pages 83-96

    5. Morphological Changes in Anterior Horn Cells, Immunoreactivity to Neurotrophic Factors, and Neuronal Cell Death of Spinal Cord Lesions in the Spinal Hyperostotic Mouse (twy/twy) with Chronic Mechanical Cord Compression

      • Kenzo Uchida, Hideaki Nakajima, Shoei Furukawa, Tomoo Inukai, Yasuhisa Maezawa, Hisatoshi Baba
      Pages 97-106

    6. In Vivo Tracing of Neural Tracts in Tiptoe-Walking Yoshimura Mice by Diffusion Tensor Tractography

      • Morito Takano, Yuji Komaki, Keigo Hikishima, Tsunehiko Konomi, Kanehiro Fujiyoshi, Osahiko Tsuji et al.
      Pages 107-117

    7. Microarray Analysis of Expression of Cell Death-Associated Genes in Spinal Cord Cells with Cyclic Tensile Strain

      • Kenzo Uchida, Hideaki Nakajima, Takayuki Hirai, Sally Roberts, William E. B. Johnson, Hisatoshi Baba
      Pages 119-127

    8. Spinal Kyphosis Causes Demyelination and Neuronal Loss in the Spinal Cord

      • Masaya Nakamura, Kentaro Shimizu, Yoshiaki Toyama
      Pages 129-138

  4. Neuroprotection

    1. Front Matter

      Pages 139-139
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    2. Granulocyte Colony-Stimulating Factor-Mediated Neuroprotective Therapy for Spinal Cord Injury

      • Masao Koda, Takeo Furuya, Taigo Ianada, Koshiro Kamiya, Mitsutoshi Ota, Satoshi Maki et al.
      Pages 141-146

    3. Recombinant Human Hepatocyte Growth Factor Promotes Functional Recovery After Spinal Cord Injury

      • Kazuya Kitamura, Akio Iwanami, Kanehiro Fujiyoshi, Jun-ichi Yamane, Keigo Hikishima, Hiroshi Funakoshi et al.
      Pages 147-167

    4. The Proteoglycan-Degrading Enzymes Promote Functional Recovery After Spinal Cord Injury: Keratan Sulfate and Chondroitin Sulfate

      • Shiro Imagama, Zenya Ito, Kei Ando, Yukihiro Matsuyama, Yoshihiro Nishida, Naoki Ishiguro
      Pages 169-191

    5. Targeted Retrograde Gene Delivery into the Injured Spinal Cord Using Recombinant Adenovirus Vector Carrying Neurotrophic Factor Gene

      • Hideaki Nakajima, Kenzo Uchida, Takafumi Yayama, Kazuya Honjoh, Takumi Sakamoto, Hisatoshi Baba
      Pages 193-201
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Keywords

About this book

Neuroprotection and Regeneration of the Spinal Cord comprehensively covers the most recent research in the field of spinal cord injury. The first part of this book focuses on the latest animal models and clinically oriented work, providing extensive information on morphological factors and, biomechanical analysis, in addition to the mechanism of functional recovery. The book goes on to provide information on clinical relevance introducing analysis of spinal cord injuries using MRI and PET. Edited by renowned experts in the field, this book will provide clinical physicians, basic researchers and postgraduate students with valuable insight into the cutting-edge research and progress in the field of spinal cord injury, treatment and repair.

Reviews

From the reviews:

“This is an excellent book covering the latest in the pathology, histology, animal models, and stem cell research regarding acute spinal cord damage. … There is a good audience to neurologists, neurosurgeons, research fellows, and medical students working in SCI Research. I highly recommend this book to all interested audiences.” (Joseph J. Grenier, Amazon.com, March, 2014)

Editors and Affiliations

  • Dept of Orthop & Rehabilit Med, University of Fukui Faculty of Medical Sciences, Yoshida-gun, Japan

    Kenzo Uchida

  • Department of Orthopaedic Surgery, Keio University School of Medicine, Tokyo, Japan

    Masaya Nakamura, Yoshiaki Toyama

  • Department of Orthopaedic Surgery, Tohoku University Graduate School of Medicine, Sendai, Japan

    Hiroshi Ozawa

  • Department of Orthopedic Surgery, Faculty of Medicine The University of Tokushima, Tokushima, Japan

    Shinsuke Katoh

About the editors

Honorary Editor: Yoshiaki Toyama, Keio University School of Medicine, Shinjuku, Tokyo, Japan (MD, PhD, Professor) Editors: Hisatoshi Baba, Fukui University School of Medicine, Matsuoka, Fukui, Japan (MD, PhD, Professor) Shinsuke Katoh, The University of Tokushima, Tokushima, Japan (MD, PhD, Professor) Masaya, Nakamura, Tokyo, Japan (MD, PhD, Associate Professor) Hiroshi Ozawa, Tohoku University, Sendai, Japan (MD, PhD, Associate Professor) Kenzo Uchida, University of Fukui, Matsuoka, Fukui, Japan (MD, PhD, Associate Professor).

                                      

Bibliographic Information

  • Book Title: Neuroprotection and Regeneration of the Spinal Cord

  • Editors: Kenzo Uchida, Masaya Nakamura, Hiroshi Ozawa, Shinsuke Katoh, Yoshiaki Toyama

  • DOI: https://doi.org/10.1007/978-4-431-54502-6

  • Publisher: Springer Tokyo

  • eBook Packages: Medicine, Medicine (R0)

  • Copyright Information: Springer Japan 2014

  • Hardcover ISBN: 978-4-431-54501-9Published: 18 March 2014

  • Softcover ISBN: 978-4-431-56150-7Published: 03 September 2016

  • eBook ISBN: 978-4-431-54502-6Published: 08 July 2014

  • Edition Number: 1

  • Number of Pages: X, 419

  • Number of Illustrations: 77 b/w illustrations, 90 illustrations in colour

  • Topics: Orthopedics, Surgical Orthopedics, Neurology, Head and Neck Surgery, Neurosurgery

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