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Metastatic Bone Disease

An Integrated Approach to Patient Care

Editors:

  • Covers all aspects of surgical and medical intervention in metastatic bone disease for orthopedic surgeons and oncologists
  • Presents mechanistic biology, work-up, medical therapy, radiation and interventional oncology, principles and techniques of orthopedic surgical oncology and emerging technologies
  • Features rich and detailed images for diagnostic and referential purposes

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Table of contents (31 chapters)

  1. Front Matter

    Pages i-xiii
  2. The Problem

    1. Front Matter

      Pages 1-1
    2. Bone Metastases: Epidemiology and Societal Effect

      • Robert U. Ashford, R. Lor Randall
      Pages 3-11
  3. Biology of Metastases and Tissue of Origin Considerations

    1. Front Matter

      Pages 13-13
    2. Pathobiology of Osteolytic and Osteoblastic Bone Metastases

      • Antonella Chiechi, Theresa A. Guise
      Pages 15-35
    3. Biology of Bone Cancer Pain

      • Patrick W. O’Donnell, Denis R. Clohisy
      Pages 37-44
    4. Breast Cancer Bone Metastases

      • Sarah Colonna, Theresa L. Werner
      Pages 45-54
    5. Prostate Cancer Bone Metastasis

      • Jonathan D. Tward
      Pages 55-64
    6. Lung

      • Shamus R. Carr
      Pages 65-69
    7. Kidney Metastatic Bone Disease

      • Patrik Luzny, Christopher Dechet
      Pages 71-83
    8. Thyroid

      • Elie Klam, Dev Abraham
      Pages 85-88
    9. Myeloma

      • Srinivas K. Tantravahi, Tibor Kovacsovics
      Pages 89-100
  4. Work-Up for Patients with Suspected Metastatic Bone Disease

    1. Front Matter

      Pages 101-101
    2. Evaluation of the Patient with Carcinoma of Unknown Origin Metastatic to Bone

      • Bruce T. Rougraff, Terence J. Cudahy
      Pages 103-109
    3. Biopsy Considerations

      • Daniel M. Lerman
      Pages 111-117
  5. Medical Therapy

    1. Front Matter

      Pages 119-119
    2. Bisphosphonates, Denosumab, and Anabolic Agents in the Treatment of Metastatic Bone Disease

      • Z. Deniz Olgun, Arianna Gianakos, Jonathan E. Jo, Joseph M. Lane
      Pages 121-129
    3. Biotargeting in Metastatic Bone Disease

      • Anna R. Cooper, Wakenda Tyler, Emily E. Carmody
      Pages 131-142
  6. Supportive Oncology

    1. Front Matter

      Pages 143-143

About this book

Providing an integrated approach to the diagnosis and management of patients with metastatic bone disease (MBD), this comprehensive text combines discussion of the pathobiology of the disease with the latest oncological and orthopedic treatment modalities. After opening with an examination of the epidemiology and impact of MBD, the biology of bone metastases are discussed, along with considerations of the tissue of origin. Evaluation, biopsy and medical therapy, including metabolic agents and bio targeting. The heart of the book presents oncological approaches (supportive, radiation and interventional) and principles of orthopedic surgical oncology, with subsequent chapters covering specific anatomy, from the pelvis to the lower extremity and the spine. Chapters on emerging surgical technology and future directions conclude the text and redefine an integrated approach to patient care. Taken together, Metastatic Bone Disease is an excellent resource for orthopedic surgeons andcancer specialists alike.  

Editors and Affiliations

  • Huntsman Cancer Institute, The University of Utah, Salt Lake City, USA

    R. Lor Randall

About the editor

R. Lor Randall, MD, FACS, The L.B. & Olive S. Young Endowed Chair for Cancer Research Director, Sarcoma Services & Medical Director, HCI Surgical Services Chief, SARC Lab & Fellowships Co-Leader, Sarcoma Disease Oriented Research Team, Professor of Orthopaedics, Primary Children's Hospital & Huntsman Cancer Institute, The University of Utah Salt Lake City, UT.

Bibliographic Information

  • Book Title: Metastatic Bone Disease

  • Book Subtitle: An Integrated Approach to Patient Care

  • Editors: R. Lor Randall

  • DOI: https://doi.org/10.1007/978-1-4614-5662-9

  • Publisher: Springer New York, NY

  • eBook Packages: Medicine, Medicine (R0)

  • Copyright Information: Springer Science+Business Media New York 2016

  • Hardcover ISBN: 978-1-4614-5661-2Published: 02 December 2015

  • Softcover ISBN: 978-1-4939-7933-2Published: 27 March 2019

  • eBook ISBN: 978-1-4614-5662-9Published: 01 December 2015

  • Edition Number: 1

  • Number of Pages: XIII, 368

  • Number of Illustrations: 50 b/w illustrations, 35 illustrations in colour

  • Topics: Orthopedics, Oncology

Buy it now

Buying options

eBook USD 79.99
Price excludes VAT (USA)
  • Available as EPUB and PDF
  • Read on any device
  • Instant download
  • Own it forever
Softcover Book USD 99.99
Price excludes VAT (USA)
  • Compact, lightweight edition
  • Dispatched in 3 to 5 business days
  • Free shipping worldwide - see info
Hardcover Book USD 139.99
Price excludes VAT (USA)
  • Durable hardcover edition
  • Dispatched in 3 to 5 business days
  • Free shipping worldwide - see info

Tax calculation will be finalised at checkout

Other ways to access