Developing Insights in Cartilage Repair

1. Front Matter

   Pages i-xiv

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2. Introduction

   1. Front Matter

      Pages 1-1

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   2. General Introduction

      • Pieter J. Emans, Lars Peterson

      Pages 3-18

3. Fundamental Research, Biomaterials and Bioreactor Involved in Cartilage Repair

   1. Front Matter

      Pages 19-19

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   2. Gene Therapy in Articular Cartilage Repair

      • Alan Ivkovic, Andreja Vukasovic, Ryan M. Porter, Damir Hudetz, Marko Pecina, Christopher H. Evans

      Pages 21-41

   3. Targeting Inflammatory Processes for Optimization of Cartilage Homeostasis and Repair Techniques

      • Marjolein M. J. Caron, Tim J. M. Welting, Lodewijk W. van Rhijn, Pieter J. Emans

      Pages 43-63

   4. Osteoarthritis: Molecular Mechanisms and Treatments

      • Takehiko Matsushita, Ryosuke Kuroda

      Pages 65-77

   5. Bioreactor Tissue Engineering for Cartilage Repair

      • Gian M. Salzmann, Martin J. Stoddart

      Pages 79-97

   6. Biomaterials for Osteochondral Reconstruction

      • Elizaveta Kon, Francesco Perdisa, Giuseppe Filardo, Luca Andriolo, Francesco Tentoni, Maurilio Marcacci

      Pages 99-108

4. Imaging of Cartilage

   1. Front Matter

      Pages 109-109

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   2. Advanced Magnetic Resonance Imaging of Cartilage Repair

      • Goetz H. Welsch, Friedrich F. Hennig, Siegfried Trattnig

      Pages 111-128

5. Cartilage Repair Techniques

   1. Front Matter

      Pages 129-129

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   2. Osteochondral Allograft Transplantation: The Rationale and Basic Science

      • Patrick C. McCulloch, Simon Görtz

      Pages 131-147

   3. Osteochondral Allograft Transplantation: Surgical Technique and Results

      • Simon Görtz, Patrick C. McCulloch

      Pages 149-160

   4. The Genesis of Autologous Chondrocyte Transplantation/Implantation: From a Hypothesis via an Animal Model to a Clinical Reality

      • Lars Peterson

      Pages 161-185

   5. Characterized Chondrocyte Implantation Challenges Current Paradigms for the Treatment of Symptomatic Joint Surface Lesions

      • J. Vanlauwe, M. Jelic, M. J. Limbourg, F. P. Luyten

      Pages 187-209

6. Other Aspects of Cartilage Repair

   1. Front Matter

      Pages 211-211

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   2. Autologous Chondrocyte Implantation After Previous Treatment with Marrow Stimulation Techniques

      • Marco K. Demange, Tom Minas, Andreas H. Gomoll

      Pages 213-225

   3. Arthroscopic Approaches for Cartilage Repair in the Knee Joint

      • Enrique Villalobos Jr., Anell Olivos-Meza, Aldo Izaguirre, Clemente Ibarra

      Pages 227-239

   4. Articular Cartilage Repair of the Knee in Athletes

      • Robert H. Brophy

      Pages 241-252

This comprehensive book discusses cartilage repair and all its aspects. These aspects vary from basic insights in cartilage biology and regeneration via MRI, to results of existing cartilage repair techniques and upcoming novel approaches. Fundamental cartilage biology is the topic covered within the first chapters of the book. These chapters not only provide an insight in healthy, damaged and regenerative cartilage but also describe developments in gene therapy and methods to enhance chondrogenesis of stemcells and prevent hypertophic differentiation. There is a huge progress in the possibilities of MR imaging of both healthy, damaged and regenerative cartilage. These developments not only enable better monitoring of cartilage repair but may also unravel the pathophysiology of the development of cartilage defects. Different cartilage repair techniques (e.g. allografts, autologous chondrocytes transplantation [ACT], microfracture), there technical aspects (e.g. developments towards an total arthroscopic approach), pitfalls, and outcomes are reported in the following chapters. In these chapters factors important for the results of cartilage repair such as meniscal repair, patient factors are described. Finally, an overview of novel cartilage repair techniques such as minced cartilage, denovo cartilage and more areas are discussed in this comprehensive addition to the literature.

• Cartilage Repair
• Cartilage Replacement
• Emerging Techniques
• Imaging Techniques
• Orthopedics

• Department of Orthopaedic Surgery, Maastricht University Medical Center, Maastricht, The Netherlands

  Pieter J. Emans

• Department of Orthopedics, University of Gothenburg, Gothenburg, Sweden

  Lars Peterson

Pieter Emans of the Department of Orthopaedic Surgery, University Hospital Maastricht, The Netherlands and Lars Peterson, Professor of Orthopaedic Surgery at University of Gothenburg, Sweden.

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