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Medicine - Ophthalmology | Retinal Degenerations - Biology, Diagnostics, and Therapeutics

Retinal Degenerations

Biology, Diagnostics, and Therapeutics

Tombran-Tink, Joyce, Barnstable, Colin J. (Eds.)

2007, XIX, 466 p. With CD-ROM.

A product of Humana Press
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This book focuses on what we currently know about the environment, genetics and mechanisms that lead to retinal degenerations, new diagnostics, and innovative therapeutic modalities to preserve vision. Written by renowned scientific investigators, this innovative collection of treatment strategies and technological discoveries allows for the realistic translation of research into practice. Following an exciting preface describing the diagnosis and treatment of retinal degenerations from antiquity to the modern era, this four-part volume begins with thought-provoking portraits of the reality of life with retinal degenerations. In Part II, researchers and practitioners examine seven different retinal diseases. Part III discusses our current understanding of the underlying mechanisms of retinal degeneration, and in Part IV, the challenges of therapeutic strategies for retinal degenerative diseases are emphasized as researchers discuss cutting-edge treatments.

This book brings the scientific community to the frontline of research into diseases of the retina and challenges scientists in academia and the pharmaceutical industry to develop innovative strategies for the transla

Content Level » Professional/practitioner

Keywords » aging - apoptosis - biology - cell - death - diabetes - diagnostics - genetics - macular degeneration - mutation - protein - receptor - retina - stem cell - stem cells

Related subjects » Cell Biology - Neuroscience - Ophthalmology

Table of contents 

Retinal Degenerations: Genetics, Progression, and Therapeutics - Table of Contents J Tombran-Tink and CJ Barnstable (eds) University of Missouri-Kansas City and Yale University School of Medicine 1. Living with Retinal Degeneration Coping with Retinitis Pigmentosa: A Patientís View Gordon Cousins and James Cape 2. Degenerative Diseases of the Retina Epidemiology of ARMD Early in the 21st Century Jie Jin Wang, Paul Mitchell and Ronald Klein 3. Leber Congenital Amaurosis: Biology, Diagnostics, and Therapeutics Robert K. Koenekoop 4. Macular Degeneration. Aging Changes and Novel Therapies Peter E. Liggett and Alejandro J. Lavaque 5. Stargardt Disease: from gene discovery to therapy Rando Allikmets 6. X-Linked Juvenile Retinoschisis Bernhard H.F. Weber and Ulrich Kellner 7. Retinal Degeneration in Usher Syndrome David S. Williams 8. Mouse models of RP Bo Chang, Norman L. Hawes, Muriel T. Davisson, J.R. Heckenlively 9. Mechanisms underlying retinal degenerations The Impact of Diabetes on Neuronal, Glial and Vascular Cells of the Retina: Implications for the Pathogenesis of Diabetic Retinopathy Sylvia B. Smith 10. Statins and Age-Related Maculopathy Gerald McGwin Jr. and Cynthia Owsley 11. The role of Drusen in Macular Degeneration and New Methods of Quantification R. Theodore Smith and Umer F. Ahmad 12. RPE lipofuscin: Formation, Properties, and Relevance to Retinal Degeneration Janet R. Sparrow 13. Genetic Modifiers that Affect Phenotypic Expression of Retinal Diseases Malia M. Edwards, Dennis M. Maddox, Jungyeon Won, J¸rgen K. Naggert and Patsy M. Nishina 14. X-linked retinal dystrophies and microtubular functions within the retina Alan Wright and Xinhua Shu 15. Synaptic Remodeling in RetinalDegeneration You-Wei Peng and Fulton Wong 16. Developing Therapeutic Strategies for Retinal Degenerative Diseases On The Suppression of Photoreceptor Cell Death in Retinitis Pigmentosa Fiona Kernan, Alex G. McKee, G. J. Farrar and Peter Humphries 17. Cell-based therapies to restrict to progress of photoreceptor degeneration Raymond D. Lund and Shaomei Wang 18. Current Status of IPE Transplantation and its Potential as a Cell-Based Therapy for Age-Related Macular Degeneration and Retinal Dystrophies Makoto Tamai 19. Recent results in Retinal Transplantation give hope for restoring vision Robert B. Aramant, Norman D. Radtke and Magdalene J. Seiler 20. Stem Cells and Retinal Transplantation Joanne Yau, Henry Klassen, Tasneem Zahir and Michael Young 21. Application of Encapsulated Cell Technology for Retinal Degenerative Diseases Weng Tao and Rong Wen 22. Effective treatment for the canine RPE65 null mutation, a hereditary retinal dystrophy comparable to human Leberís Congenital Amaurosis Kristina Narfstrˆm, Gregory E. Tullis and Mathias Seeliger 23. The Use of Neuroprotective Factors in Retinal Degenerations Joyce Tombran-Tink and Colin Barnstable 24. Carbonic anhydrase inhibitors as a possible therapy for RP17, an Autosomal Dominant Retinitis Pigmentosa associated with the R14W mutation, apoptosis, and the unfolded protein response. George Rebello, Jacquie Greenberg and Raj Ramesar

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